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> 한국산업보건학회 (구 한국산업위생학회) > 한국산업보건학회지 > 27권 3호

환경오염원인 납의 신경독성에 대한 NMDA 수용체 길항제의 보호 효과

Protective Effect of NMDA Receptor Antagonist on the Neurotoxicity Induced by Lead as an Environmental Pollutant

손영우 ( Young-wo-son ) , 임요섭 ( Yo-sup Rim ) , 서영미 ( Young Mi Seo )

- 발행기관 : 한국산업보건학회 (구 한국산업위생학회)

- 발행년도 : 2017

- 간행물 : 한국산업보건학회지, 27권 3호

- 페이지 : pp.193-200 ( 총 8 페이지 )


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논문제목
초록(외국어)
Objectives: This study was performed to evaluate the neurototoxicity of the environmental pollutant lead acetate(LA) and the protective effect of the D-2-amino-5-phosphonovaleric acid(APV), N-methyl-D-aspartate(NMDA) receptor antagonist on LA-induced cytotoxicity in cultured C6 glioma cells. Materials and Methods: For this study, cell viability in cultured C6 glioma cells was assessed by XTT assay and antioxidative effect, such as lactate dehydrogenase(LDH) activity, by LDH detection kit. Results: LA significantly decreased cell viability in a dose-dependent manner, and the XTT50 value was determined to be 33.3 uM of LA. The cytotoxicity of LA was deemed highly toxic according to Borenfreund and Puerner`s toxic criteria. The vitamin E antioxidant significantly increased cell viability damaged by LA-induced cytotoxicity in these cultures. For the protective effect of APV on LA-induced cytotoxicity, APV significantly increased not only cell viability, but also inhibition of LDH activity. From these results, it is suggested that oxidative stress is involved in the neurotoxicity of LA, and APV effectively protected against LA-induced cytotoxicity via an antioxidative effect as an inhibotory activity of LDH. Conclusions: Natural resources like APV may be putative therapeutic agents for the toxic diminution of environmental pollutants such as LA correlated with oxidative stress.

논문정보
  • - 주제 : 의약학분야 > 예방의학및보건학
  • - 발행기관 : 한국산업보건학회 (구 한국산업위생학회)
  • - 간행물 : 한국산업보건학회지, 27권 3호
  • - 발행년도 : 2017
  • - 페이지 : pp.193-200 ( 총 8 페이지 )
  • - ECN : I410-ECN-0102-2018-500-000691178
  • - UCI : I410-ECN-0102-2018-500-000691178
저널정보
  • - 주제 : 의약학분야 > 예방의학및보건학
  • - 성격 : 학술지
  • - 간기 : 계간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : -
  • - ISSN : 2384-132x
  • - 수록범위 : 1991–2018
  • - 수록 논문수 : 923