The purpose of the study was to determine a relationship between family caregiver`s knowledge on schizophrenia and coping on problem behaviors of patients with schizophrenia. A descriptive correlational study was conducted. A total of 57 family caregivers with schizophrenic patients participated in this study. The instruments, Knowledge Scale, and Coping Scale were used in this study. Knowledge Scale designed by the research team was composed of 28 items including cause(5 items), treatment(5 items), symptoms(5 items), medications(5 items), and relapse(5 items). For Knowledge scale, the cronbach`s alpha was 0.81. Coping Scale with 22 items designed by the research team was composed of negative coping and positive coping. Among 22 items of Knowledge scale, 6 items were removed since of low reliability. Revised coping scale with 16 items was used. For internal consistency, cronbach`s alpha of revised coping scale was 0.74. Confirmatory factor analysis for the revised coping scale indicated four significant factors which explained 63.6% of the variance. Four factors were named as positive coping with verbal behavior, positive coping with help seeking, negative coping with passive behavior, and negative coping with active behavior. The results show that there is a significant negative relationship between caregiver`s knowledge on schizophrenia and negative coping with passive behavior toward patients` problem behaviors(r=-.28, p<.05). This indicates that the more family caregivers have a lack of knowledge on patient`s disease, the more family caregivers use negative coping with passive behavior. The findings in this study have implications for coping strategies and suggest the need to provide the knowledge on patient`s disease to family caregivers caring patients with schizophrenia. The data in this research suggest that providing the knowledge of patient`s disease to family caregivers ins a nursing intervention, which is highly structured and systematic approach that involved using caregivers` effective coping strategies.