To keep enterprise`s competitiveness on condition of the automatic manufacturing system such as 1`A, FMS and CIM, all the maintenance problems should be considered seriously in not only production and maintenance but also related industrial safety. As we analyze for in the surveys about the maintenance management of domestic enterprises and the causes of industrial accident, there will be necessity of drawing up countermeasures for prevention of industrial accidents and for ensuring expertise maintenance technologies. Based on these analyses, the safety information system, maintenance management information system, and the machinery condition diagnosis technique are studied by using of the knowledge-based system under the real time computer operating environment. This computer based knowledge-based diagnosis system can easily provide the knowledge of expert system about deterioration phenomenon of industrial robot and the knowledge information of relating safety and facility on everywhere, everytime. Therefore, when we use this system, it is expected to improve the efficiency of business processes in the production and safely.