Purpose : The purpose of this study was to develop a school-based comprehensive smoking cessation program and to test its effectiveness. Method : The study design was quasi-experimental with pre and three posttests. Total 43 high school students participated in the study, 22 in experimental group and 21 in control group. To identify the long-time effectiveness of the program, participants were followed after 3 and 6 months. The program was made up total 9 sessions took 40-50 minutes for one session and was provided twice a week. To test the effectiveness of the program, nicotine dependency, urine cotinine level, self-efficacy, and stress level were used as dependent variables. Results : Nicotine dependency, self-efficacy, and stress level did not significantly changed after the program. However, urine cotinine level was significantly decreased after the program and after six month. Conclusion : The above findings indicated that the program was not effective to change self-efficacy and stress but smoking amount. Further programs need to be developed to influence on psychosocial factors such as self-efficacy and stress.