Purpose: This study was to examine the effect of the middle-school drinking-prevention program for children of alcoholics and suggest a nursing intervention program designed to help self-esteem, coping strategies, and to emotional/behavior problem for children of alcoholism. Method: This study was an equivalent control group pre-test and post-test design in quasi-experimental research. The total subjects of this study were 36 children of alcoholics(Exp.1), 41 children of social-drinker(Exp.2) & 40 children of social-drinker(Con.) residing at M-middle School in Gwangju, 117 assigned for the experimental and control group. The experimental group 1 & 2 received the middle-school drinking-prevention program, but the control group did not receive treatment. The data were collected from September, 1, 2003 to December 31, and analysed by χ²-test, ANCOVA, ANOVA, Using the SPSS 11.0 Program. Result: In the distribution of middle school students by Parents` drinking problem, social drinker group was 243(87.1%), Alcohol abuse was 29(10.4%) and alcohol dependent was 7(2.5%) among 279 students. There wasn`t significant difference in self-esteem (F=1.275, p= 0.283) by the group. But children of alcoholics was improved in self-esteem. There was a significant difference in coping strategies (F=3.499, p=0.034) by the group(F=6.165, p= 0.003)? There was a significant difference in emotional/behavior problem (F=3.499, p=0.034) by the group. Conclusion: This middle-school drinking-prevention program will be a more effective improvement of self-esteem & coping strategies and prevention of emotional/behavior problem for children of alcoholics.