Purpose: The purpose of this study was to investigate mental health status, burden and quality of life(QOL) of mothers with handicapped children. Method: Data were collected using a structured questionnaire from September to November, 2002. The subjects consisted of 65 mothers who live in D and I city. The instrument was utilized SCL-90-R, subjective and objective burden scale and QOL scale. The collected data were analyzed by SPSS program including descriptive statistics, Pearson Correlation Coefficient. Results: In the level of SCL-90-R, the mean score was 1.0642 of `depression` and 1.009 of `obsessive-compulsive`. It is that the mothers with handicapped children have mild mental health symptoms. The mean score of burden was 2.95 and it of QOL was 3.14. Burden was positive correlation with mental health status, its 9 subfactors and additional items, and negative correlation with QOL and its 6 subfactors. Also mental health status was negative correlation with QOL. Conclusion: It is necessary to develop supportive psychotherapy program for decreasing potential or actual psychologic problem in mothers with handicapped children. This study suggests that it will be done longitudinal study on emotional problem and adaptation process of parents by growth and development of handicapped children, and research on supportive program development and its effects.