Purpose: This study was done to assess effects of women focused relapse prevention program on abstinence self-efficacy and depression in alcoholic women. Methods: This study was a non-equivalent control group non-synchronized design with two groups, an experimental group (13 patients) and a control group (16 patients). The instruments were the Situational Confidence Questionnaire (SCQ-39) and the Beck depression Inventory (BOI). Data collection was done between July and December, 2008, during which a pre-test, the total of 8 group sessions for four weeks, and a post-test were given to alcoholic women who were admitted to K hospital in U city and D hospital in G city. The collected data were analyzed using descriptive statistics, Fisher`s exact test, Mann-Whitney U test and ANCOVA with SPSS/WIN program. Results: The scores for abstinence self-efficacy were significantly higher and for depression lower, for the experimental group after the women focused relapse prevention program. Conclusion: This study shows that the women focused relapse prevention program can be applied as an effective nursing intervention by clinical nurses.