Purpose: This study was conducted to test the effects of a community-based depression prevention program on community people and the effectiveness was measured by assessing depression, self-esteem, and quality of life. The theoretical framework supporting the program was Ellis` REBT (Rational Emotive Behavior Therapy) theory (1962). Methods: A nonequivalent control group pretest-posttest design was used. Study participants were 29 community residents (experimental: 14, control: 15). The depression prevention program consisted of music activity, bibliotherapy, and cognitive behavior therapy and was provided for 6 weeks (a twelve-session). Data were collected before and after the program and 3 months later for follow-up testing. Data were analyzed using the SPSSI/WIN 12.0. Results: There were no differences in outcome variables between the experimental and control groups. From the additional analyses, statistically significant differences by time point were observed for Self-esteem and Quality of life at 3 months later for experimental group. And 50% of the participants with depression symptoms no longer scored in the depression symptoms in the experimental group. Conclusion: The study findings indicate that depression prevention programs are positive in reducing depression in people suffering from depression symptoms. However some modifications are required to increase effectiveness.