Purpose: This study was conducted to investigate factors related to mental health of university student offspring according to their parents` drinking behavior. Methods: A cross-sectional design was used in this study, A convenience sample of university students were recruited from three universities in Seoul and Gyeonggi Province, Korea. Data were collected using self-report questionnaires with 547 university students. The scales used for this study were the Korean version of the Children of Alcoholics Screening Test (CAST-K), Symptom Checklist-90-Revision (SCL-90-R), Rosenberg`s Self-esteem Scale, and the Way of Coping Checklist. Results: Participants were classified into three groups; nondrinking-parents group (53.5%), social drinking-parents group (21.8%), and problem drinking-parents group (24.7%). Participants whose parents were problem drinkers had significantly higher scores on all the subcategories of SCL-90-R compared to those of other groups. In the participants group whose parents were problem drinkers, mental health problem had a significant positive correlation to passive coping methods and a negative correlation to self-esteem. There was a significant negative relationship between self-esteem and positive coping methods. Conclusion: The results of this study indicate the mental health of university students may be negatively affected by their parents` drinking behaviors. Special attention and early interventions are needed for university students whose parents have drinking problems.