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> 대한피부과학회 > 대한피부과학회지 > 50권 9호

원저 : 아토피피부염 환자에서 Cyclosporine 치료용량 및 재발인자에 대한 후향적 연구

A Retrospective Analysis of Cyclosporine Dose Regimens and Contributing Factors for Relapse in Atopic Dermatitis

노현수 ( Hyun Soo Roh ) , 김정은 ( Jeong Eun Kim ) , 고주연 ( Joo Yeon Ko ) , 노영석 ( Young Suck Ro )


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초록(외국어)
Background: The clinical efficacy of cyclosporine in the treatment of atopic dermatitis is well documented. However, the optimal dose regimen has not yet been established, and there are few published data about the factors related with relapse after cyclosporine therapy. Objective: The purpose of this study was to provide clues for the proper use of cyclosporine and identify contributing factors for relapse in atopic dermatitis. Methods: We performed a retrospective analysis of 174 patients with atopic dermatitis who had been treated with cyclosporine in our clinic between January 2007 and January 2012. Results: The mean starting dose of cyclosporine was 4.8 mg/kg, and the relief of symptoms was initially achieved with a dose of 5.0 mg/kg. Treatments were continued for 137.2 days with a cumulative dose of 388.0 mg/kg. After discontinuation of cyclosporine, 79/167 (47.3%) patients experienced a relapse, and the duration of remission was 288.6 days. In a multiple regression analysis, serum IgE (p=0.015), starting dose of cyclosporine (p=0.010), and maintenance therapy (p<0.001) were independent and significant factors related to relapse; the relapse and serum IgE, starting dose of cyclosporine showed negative relationship, and maintenance therapy considerably reduced the recurrence rate (odds ratio, 0.04). Conclusion: Our results indicate that higher starting dose of cyclosporine may decrease the relapse rate in atopic dermatitis. In the post-cyclosporine period, subsequent maintenance therapy should also be considered for sustained remission. At the beginning of cyclosporine therapy, initial serum IgE would be a good laboratory index for predicting the risk of relapse.

논문정보
  • - 주제 : 의약학분야 > 피부과학
  • - 발행기관 : 대한피부과학회
  • - 간행물 : 대한피부과학회지, 50권 9호
  • - 발행년도 : 2012
  • - 페이지 : pp.773-780 ( 총 8 페이지 )
  • - ECN :
  • - UCI : I410-ECN-0102-2013-510-002300718
의약학분야 > 피부과학 분야의 인기간행물

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저널정보
  • - 주제 : 의약학분야 > 피부과학
  • - 성격 : 학술지
  • - 간기 : 월간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : - / SCOPUS
  • - ISSN : 0494-4739
  • - 수록범위 : 1960–2017
  • - 수록 논문수 : 8761