Purpose: The purpose of this study was to evaluate the effects of a mentoring program designed to help middle school girls from low income families cope with stress and improve self-esteem. Methods: A non-equivalent control group, pretest-posttest design was used. The independent variable was the mentoring program, in which the mentors were nursing students and the mentees were middle school girls. The dependent variables were stress and self-esteem scores. The program was conducted using group activities and personal approaches through the mentor-mentee relationship. The program was conducted from September 1 to December 11, 2010 in a middle school in A city, South Korea. Results: At follow-up, the stress and mental health scores had improved significantly in the intervention group compared to the control group. The self-esteem scores in the intervention group were significantly higher after the intervention than scores before the intervention. However there was no significant difference between the two groups. Conclusion: The results of this study suggest that mentoring programs have the potential to be developmentally appropriate interventions for stress management and self-esteem improvement in adolescents from vulnerable families and also enable nursing students as mentors to gain confidence in their professional capability.