This study Shusaku Endo`s "sea and poison" in the relationship between guilt and God has been investigated mainly. First, the presence of Japanese guilt in order to identify and Tsuyoshi Toda, Jiro Suguro looked around. As a result, the resistance actively in their own destiny Suguro not pushed around by circumstances, but as a painful vivisection after the intense guilt and that guilt appears as fatigue and weakness that could see. However, the god of Christianity in the West Suguro guilt does not exist, according to the flow of time has confirmed the fact that sometimes purged. Toda and actively participate in the vivisection of past theft, adultery, and human beings can do for committing all the sins you can not even feel a pang of conscience say to myself feel fear. Thus hath to himself that there is a lack of guilt are well aware about the sins he has committed and the fact that awareness was found. Endo "The Sea and Poison", the sea, aunt, helpless American prisoners of the death of Christianity through the existence of God is present. This Suguro guilt and God hath such association is not the God of Christianity through the Japanese people realize that when the human misery and, paradoxically, God`s intention to try to recognize the need was identified.