Purpose: The purpose of this study was to evaluate the effects of the Job Stress Management Program (JSMP) combined with communication skills training for health care professionals. Methods: The study design was a nonequivalent control group pre- post test design. Study participants were 42 health care professionals in the experimental group and 38 in the control group. Eight sessions of JSMP were provided over 6 weeks, through on-line and off-line education. Data were analyzed using x2-test, t-test with the SAS 9.2 program. Results: There were statistically significant differences in job satisfaction, emotional labor, symptoms of stress, interpersonal stress, and type of communication between the experimental group and the control group. Conclusion: The results of this study indicate that the JSMP based on communication skills training developed in this study has positive, effects on job stress and communication.