In A Thousand Plateaus, Deleuze and Guattari make a startling pronouncement: "Drug users, masochists, schizophrenics, lovers-all BwOs [Bodies without Organs] pay homage to Spinoza.” This essay seeks to explain the paradoxical association of self-destruction with Spinoza`s affirmative philosophy of self-mastery. I examine how Deleuze and Guattari develop the concept of the BwO, the signal figure of their philosophy of immanence, in dialogue with Spinoza`s Ethics, and how, to reassess their exuberant championing of revolutionary deterritorialization in Anti-Oedipus, they investigate, through the figure of the "empty" BwO, the circumstances under which Spinoza`s project of becoming active can lead to subjugation.