Purpose: This study aimed to identify the level of knowledge on preventing cardiovascular disease (CVD) and nicotine dependency among smoking male college students, and to examine the predicting factors of nicotine dependency. Methods: This study was conducted as cross-sectional descriptive research using structured questionnaires. Data were collected from 411 smoking male college students (22.5±2.59 yr) at two universities located in two cities in Korea from September 2012 to April 2013. Logistic regression analysis was performed to estimate age-adjusted odds ratios of nicotine dependency. Results: The mean value of nicotine dependency was 4.2±1.96 and the percentage of participants who had strong nicotine dependency (≥7) was 10.7%. Logistic regression analysis showed that, when adjustment was made for age, nicotine dependency was predicted by the frequency of alcohol drinking (≥3 times/week), knowledge on CVD prevention, the age starting drinking, and the total length of smoking. Conclusion: Nicotine dependency was strongly related to the frequency of drinking alcohol and lower knowledge on CVD prevention. Therefore, male college students who have a dependent smoking habit and drink alcohol frequently need to take more interest in health through educational counseling to modify their lifestyle behaviors and to have preventive knowledge related to CVD.