Purpose: The purpose of this study was to investigate factors associated with perceived job satisfaction of TB control nurses in Korea. Methods: This study employed a descriptive survey research design using data for 189 TB control nurses. Variables included in this study were demographic, social, and work-related characteristics (including job stress), and job satisfaction. ANOVA, t-test, and multiple regression analyses were performed using SPSS/WIN 19.0 program. Results: The mean value of perceived job satisfaction was lower in the subjects (2.9±0.41) than in general nurses working in other departments. In multiple regression analysis, factors associated with TB control nurses’ job satisfaction were job stress (β=-.281, p<.001), marital status (β=-.229, p<.001), and the number of TB control nurses employed (β=.200, p<.001). Conclusion: The results of this study showed that job satisfaction was associated more significantly with job-related characteristics than with non-job-related variables in workplace. Along with increased TB control nurse staffing, efforts should be made to reduce negative workplace issues such as job stress and inappropriate pay to improve the subject’s job satisfaction.