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> 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) > Allergy Asthma & Respiratory Disease > 1권 3호

자작나무와 오리나무 화분의 주 알레르겐에 대한 immunoglobulin E 결합 성분의 규명

ORIGINAL ARTICLE : Identification of immunoglobulin E binding components of two major tree pollens, birch and alder

윤문경 ( Moon Gyung Yoon ) , 김미애 ( Mi Ae Kim ) , 진현정 ( Hyun Jung Jin ) , 신유섭 ( Yoo Seob Shin ) , 박해심 ( Hae Sim Park )

- 발행기관 : 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회)

- 발행년도 : 2013

- 간행물 : Allergy Asthma & Respiratory Disease, 1권 3호

- 페이지 : pp.216-220 ( 총 5 페이지 )


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4,000
논문제목
초록(외국어)
Purpose: Pollinosis is one of the major allergic diseases caused by airborne pollens. Alder and birch pollens are the major sensitizing tree pollens in this country. The immunoglobulin E (IgE) reactivity to each pollen allergen is known to be variable according to the region. We determined the major IgE binding components of these tree pollens in sera of adult patients with allergic rhinitis. Methods: Allergic rhinitis patients, of whom specific IgE level to birch and/or alder pollens (>10 kU/L by ImmunoCAP) were included. The protein bands of two pollen extracts were determined by sodium dodecyl sulphate-polyacrylamide gel electrophoresis, and their IgE-binding components were identified by IgE immunoblot analysis. The binding specificity and cross-reactivity between two pollens were evaluated by IgE enzyme linked immunosorbent assay (ELISA) inhibition test. Results: Six IgE binding components were found in birch pollens in which two (14 kDa and 17 kDa) were major components. Two IgE binding components were found in alder pollens in which the 17 kDa was a major component. The IgE binding component to the major allergen component of 17 kDa was observed in 90.3% of the study subjects sensitive to alder pollens and 72.7% of them sensitive to birch pollens. The ELISA inhibition tests showed significant inhibitions with additions of birch/alder pollen extracts. Conclusion: We identified two major IgE binding components (17 kDa and 14 kDa) from birch pollens and one component (17 kDa) from alder pollens. Significant cross reactivity was noted between these two pollens. (Allergy Asthma Respir Dis 2013;1:216-220)

논문정보
  • - 주제 : 의약학분야 > 소아과학
  • - 발행기관 : 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회)
  • - 간행물 : Allergy Asthma & Respiratory Disease, 1권 3호
  • - 발행년도 : 2013
  • - 페이지 : pp.216-220 ( 총 5 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2015-500-000272511
저널정보
  • - 주제 : 의약학분야 > 소아과학
  • - 성격 : 학술지
  • - 간기 : 격월
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : -
  • - ISSN : 2288-0402
  • - 수록범위 : 2013–2015
  • - 수록 논문수 : 208