The Q-switched neodymium-doped yttrium aluminum laser(QSNYL) is typically used to treat photodamaged skin and melasma. Fractional photothermolysis has gained popularity, because patients can be treated safely with less downtime as compared to conventional laser treatments. Fractional delivery system delivers a high peak energy to targeted chromophores with minimal risk of bulk heating. It also allows higher fluence therapy with even distance interval. Thereby, it enables efficient treatment of deeper and follicular pigmented lesions, which are known to be difficult to treat with conventional devices. Fractional QSNYL (FRx QSNYL, Tri-Beam, Jeisys Medical Inc., Seoul, South Korea) was recently developed, but its efficacy and safety have not been reported. Herein, we report 3 cases of Korean women with mild-to-moderate facial photo-damage and melasma. All the patients showed mild to moderate improvement in pigmentation, skin texture and wrinkle. Adverse effects were minimal and acceptable. The FRx QSNYL is a safe, effective treatment for photoaging and melasma in Asians.