Purpose: The purpose of this study was to investigate life stress, social support, and antepartum depression among Southeast Asian immigrant women married to Korean men. Methods: Ninety-three subjects were recruited from local women’s clinics and multicultural family support centers in D City. The instruments used were the life stress scale, social support scale, and K-EPDS. All the instruments were translated into their corresponding mother languages(Vietnamese, Cambodian, and Philippine) and notarized. Results: The item mean scores of life stress and social support were 2.65 and 3.17, respectively, on a 5-point Likert scale. The mean score of antepartum depression was 10.16, indicating that they were generally in a depressive state. A positive correlation was observed between life stress and antepartum depression (r=.59, p<.001). Social support was negatively correlated with life stress (r=-.42, p<.001) and antepartum depression (r=-.39, p<.001). The best predictors for antepartum depression were lifestress, marital satisfaction, and emotional support, and they explained 43% of the variance. Conclusion: Antepartum depression in Southeast Asian immigrant brides was significantly associated with life stress as well as lack of emotional support. Emotional support may reduce their life stress and antepartum depression.