The purpose of this study was to make a comprehensive overview of the effects of using digital textbooks in English classes. In this study, a meta-analysis method was adopted to analyze the results of 37 primary studies including the previous articles and the school reports. Ten analysis domains were selected; eight moderated variables and two dependent variables. Results of the analysis indicate that the average effect size of using English digital textbooks is .178, which means low positive effects on the students’ overall results of studying English. However, after a critical look at different effect sizes for different moderating variables and dependent variables, the results need to be noted for the cause and effect relationships. The data in the individual articles are more effective than the school reports, which suggests that bottom-up local needs of the individual articles produce better results than top-down administrative implementation of the school reports. Also, it was found that the use of English digital textbooks had little positive effects on listening and speaking but was more effective on reading, writing, grammar and vocabulary. Also, the results showed that English digital textbooks were highly effective to the formation of positive attitude toward studying English and promoting self-directed learning among students.