Employee‘s adoption for the Six Sigma program plays an important role in increasing an organization’s innovation performance in the service industry. This study investigates how Six Sigma has an influence on employees’ adoption for its implementation program in an ICT service company. Three critical software factors such as leadership, empowerment and reward were employed to measure employees’ adoption level which is highly associated with the successful implementation of the Six Sigma program. Using empirical survey data collected from 232 people in a case company, the relationships between three factors and Six Sigma adoption were examined via the structural equation modeling technique. The result reveals that leadership does not directly affect employee’s adoption in Six Sigma program, having an indirect effect on it through empowerment or/and reward. This will help top management achieve effective implementation of Six Sigma practices.