This study identified the relationships among subjective health status, wisdom, and self-care agency of Korean older adults. Methods: The participants were 274 older adults from Daegu, aged over 65 years. Data were collected by visiting two social welfare centers, two senior welfare centers, and nine senior centers in Daegu from January 18 to February 5, 2013. Data were analyzed through one-way ANOVA, independent t-test, Pearson’s correlation, and stepwise multiple linear regression using the IBM SPSS/WIN 19.0 statistical program. Results: A significant positive correlation was found among older adults’ subjective health status, wisdom, and self-care agency. Self-care agency was affected by wisdom (47%, β=.55), the physical component summary (18%, β=.31) and mental component summary (1%, β=.12) of subjective health status, and the absence of disease (2%, β=.13). Conclusion: This study suggests that nursing interventions to promote self-care agency in older adults should be developed based on the characteristics of their subjective health status and wisdom.