Purpose: The aim of this study was to analyze knowledge development as presented in articles that were published from 2010 to 2014 in the Journal of Korean Academy of Psychiatric and Mental Health Nursing (JKPMHN) and to identify the nature of research trends. Methods: Descriptive statistics based on knowledge development classifications were used to analyze 189 articles. Results: Prominent research trends in JKPMHN were empirical knowledge in the pattern of knowing in nursing, situation-relating theory on levels of theories in nursing, inferential focus on cognitive needs for nursing epistemology, and client domain for nursing. Conclusion: The major research trends in JKPMHN were empirical and inferential knowledge. Nursing research that balances knowledge development and domains are needed.