Potential Harmful Effects of Bulk Titanium Dioxide in Risk and Hazard Assessment

Sun-kyoung Yoo; Igchun Eom; Hee Young Ro; Philje Kim; Hyo Jung Yoon; Eun Hye Jo; Kyung Hee Choi

한국환경분석학회 한국환경분석학회지 Potential Harmful Effects of Bulk Titanium Dioxide in Risk and Hazard Assessment

( Sun-kyoung Yoo ) , ( Eun Hye Jo ) , ( Igchun Eom ) , ( Hyo Jung Yoon ) , ( Hee Young Ro ) , ( Philje Kim ) , ( Kyung Hee Choi )

한국환경분석학회 2016.06

한국환경분석학회지 19권 2호 72-79(8pages)

UCI I410-ECN-0102-2017-530-000312452

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초록

In 2010, approximately 400,000 tons of titanium dioxide (TiO2) was produced, used and imported in Korea. TiO2 is mainly used as a pigment in paints and paint additives and as a white colorant in foods, cosmetics, drugs, sunscreen, textiles, and toothpaste. To control risks and manage the health and safety concerns of TiO2, the potential risk assessment of TiO2 in humans was investigated in this article. All available reliable studies that investigated TiO2 toxicity were collected by searching the literature for relevant papers. For filling the data gap, the reproductive and developmental toxicity of TiO2 was evaluated using rats. The particle size of TiO2 assessed in this report was >100 nm (except nano-sized TiO2). In repeated inhalation toxicity test, the lung lymph node burdens of TiO2 increased in a concentration-dependent manner and inflammation was noted in bronchoalveolar lavage cells. The tumors observed in rats are thought to be secondary to particle overload in inhalation carcinogenicity studies. There was no indication of any reproductive toxicity in parent animals or developmental toxicity in pups. This study indicated that TiO2 possesses properties that have potential harmful impact on human health due to repeated dose toxicity and carcinogenicity via inhalation.

키워드

Carcinogenicity

Repeated dose toxicity

Risk assessment

Titanium dioxide

참고문헌 (32)

[자료제공 : 네이버학술정보]

1. NIER (National Institute of Environmental Research)Korea., (2011),“Survey on circulation volume and use pattern of titanium dioxide”, The Republic of Korea.

2. NIOSH (National Institute for Occupational Safety and Health) Department of Health and Human Services, “Occupational Exposure to Titanium Dioxide”, 2011.

3. Jovanovic B, “Critical review of public health regulations of titanium dioxide, a human food additive”, Integr Environ Assess Manag, 11(1), 10-20.

4. NAS (National Academies of Science), Titanium Dioxide Smoke. In Toxicity of Military Smokes and Obscurants, Volume 2. Subcommittee on Military Smokes and Obscurants, National Research Council, National Academies of Science, available, http://www.nap.edu/books/0309063299/html/68.html, 1999.

5. Lewis RJ., (2002),“Hawley's Condensed Chemical Dictionary, 14th ed. ISBN 0-471-05532-8.”, John Wiley &Sons, Inc. , New York.

6. Application of Titanium Dioxide to Whiten Mozzarella Cheese

7. Lorenz K and Maga J., (1973),“Functional and sensory properties of titanium dioxide as a flour and bread additive. Food Prod”, Develop, 7, 93-98.

8. Carlson PO., Cohan AN, and Gray JC (1972), “Clouding agents for incorporation into a dry beverage mix”, US Patent 3 658 552 [25 April, 1972], Chem. Abstr., 77:18401f.

9. Detert., ER, Buchholz W (1971), “Tobacco wrapping especially for cigarettes”, German Patent 2 008 150[21 Oct, 1971], Chem. Abstr., 76: 23185x.

10. WHO (World Health Organization), International Programme on Chemical Safety, Environmental Health Criteria 24. Titanium, available, http://www.inchem.org/documents/ehc/ehc/ehc24.htm, 1982.

11. OECD, Test No. 421: Reproduction/Developmental Toxicity Screening Test, available, http://www.oecd-ilibrary. org/environment/test-no-421-reproduction-devel opmental-toxicity-screening-test_9789264070967-en, 1995.

12. NIER (National Institute of Environmental Research)Korea., (2011),“Repeated dose 28-day oral toxicity study of Titanium dioxide in SD rats (Study No. TBH-547 (KG-2011-222)”, The Republic of Korea.

13. ECHA (European Chemical Agency), ECHA Chem, Registered substance-Titanium dioxide, http://echa.eu ropa.eu/web/guest/information-on-chemicals/registere d-substances, 2006.

14. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration

15. Biological Effects and Toxicity Assessment of Titanium Dioxides: Anatase and Rutile

16. Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility.

17. Characterization and reclassification of titanium dioxide-related pulmonary lesions.

18. Pulmonary response of rats exposed to titanium dioxide (TiO 2) by inhalation for two years

19. Long-Term Pulmonary Responses of Three Laboratory Rodent Species to Subchronic Inhalation of Pigmentary Titanium Dioxide Particles

20. Comparison of results from mouse bone marrow chromosome aberration and micronucleus tests.

21. Induction of sister chromatid exchanges and micronuclei by titanium dioxide in Chinese hamster ovary-K1 cells.

22. Effects of particle exposure and particle-elicited inflammatory cells on mutation in rat alveolar epithelial cells.

23. An in vitro blood culture for evaluating the genotoxicity of titanium dioxide: the responses of antioxidant enzymes.

24. IARC monographs on the evaluation of carcinogenic risks to humans. Ingested nitrate and nitrite, and cyanobacterial peptide toxins.

25. Stamper, JW, (1970) “Titanium. In: Mineral facts and problems, Washington, DC, United States Department of Interior, pp”, 1970, 773-794.

26. FDA (U.S. Food and Drug Administration), Titanium dioxide, available: http://www.fda.gov/Food/default.htm 2011.

27. Shevtova, VM, “Data on the effect of titanium and zirconium ore dust on workers and on animaIs in chronic expriments (Russ.)”, Gig. Tr. Prot. Zabol. 1968, 12, 24-29.

28. Inhalation toxicity study on rats exposed to titanium tetrachloride atmospheric hydrolysis products for two years

29. A Cohort Mortality Study among Titanium Dioxide Manufacturing Workers in the United States

30. Mortality Among Workers Employed in the Titanium Dioxide Production Industry in Europe

31. Hext PM., Tomeson JA, and Thompson P, (2005),“Titanium Dioxide: Inhalatoin toxicity and epidemiology”, Ann. Pccup. Hyg, 49(6), 461-472

32. Titanium dioxide deposition and adenocarcinoma of the lung.