This study was conducted to survey female Vietnamese marriage immigrants’ life stress and to analyze factors influencing their life stress and coping strategies. Methods: As descriptive correlation research, this study conducted a survey with 182 conveniently sampled subjects. Data were collected in June, 2015, and analyzed with descriptive statistics, t-test, ANOVA, Pearson’s correlation coefficient, and stepwise multiple regression. Results: The subjects’ life stress levels were above average, and significantly varied according to their health, and economic status. Stress coping strategies used by the subjects included assistance seeking, problem avoidance, wishful thinking, problem solving, and emotional alleviation in the order of frequency. As a result of the stepwise multiple regression, economic level, economic activity, and health status were found to be the most significant factors influencing the subjects’ life stress, and these variables explained 45.1% of the variation in life stress. Conclusion: Female marriage immigrants were experiencing above-average life stress, and they were coping with it mainly in terms of assistance seeking or problem avoidance. In order to mitigate their stress, therefore, it is necessary to provide extended employment opportunities and economic activities for them so that they can cultivate their abilities in health management.