Recently there is a growing interest in the airborne spread. In particular, there is growing interest in secondary infection through the air in the hospital. The distribution of airbone virus depends on the type of HVAC system installed in a hospital. So, a study was progressed Multi-zone simulation in case of applying to EHP system or AHU system in the hospital. When applying the AHU system was distributed low pollution as compared with the case of applying the EHP system. When applying the AHU system was distributed the pollution more extensive as compared with the case of applying the EHP system. In the rest result, show that corridors and elevator hall and air duct is main moving path of the virus. Accordingly, it have to be managed by installing the air sterilizer on the moving path.