Purpose: This study was done to examine the relation of self-esteem, stress, social support, and quality of life on fishermen`s and to identify factor influencing quality of life. Methods: Data were collected from 120 the fishermen`s who trained at the sailors educational institution located in Busan, Korea. The collected data were analyzed by descriptive statistics, t-test, ANOVA, and stepwise multiple regression. Results: The quality of life shows a positive correlation with self-esteem and social support, and a negative correlation with stress. The results of multiple regression analysis show that significant variables influencing the quality of life are stress, self-esteem, social support, and job satisfaction. And these variables explained 62.7% of the varience in quality of life. Conclusion: The study results suggest that stress is the main factor influencing fishermen`s quality of life and therefore a variety of interventions designed to lower stress levels are needed. In addition, comprehensive programs that can increase the levels of fishermen`s self-esteem, social support, and job satisfaction need to be implemented.