Purpose: This study was done to provide a basis for effective patient safety management activities and quality improvement by identifying the relationship among psychiatric nurses` perception of the healthcare accreditation system, safety climate and patient safety management activities. Methods: The study participants included 163 psychiatric nurses from 8 mental hospitals and data was collected using self-report questionnaires. Collected data were analyzed with the SPSS/WIN 21.0 using mean, t-test, ANOVA, Pearson correlation coefficient and multiple regression analysis. Results: Main factors which affect patient safety management activities are education and organizational structure for accreditation, and the total career record. The explanatory power for patient safety management activities of these variables was 41%. Conclusion: Findings indicate that psychiatric institutions have to develop their own effective measures, work out plans to support administrative and financial nursing services, and continuously provide useful information and educational opportunities.