Purpose: The purpose of this study was to analyze factors influencing health-related quality of life (HRQoL) among male adults. Methods: Participants were 196 male adults who were recruited from June to July 2016. Seven variables related to HRQoL including age, perceived stress, physical activities, problem drinking, social support, self-esteem, depression were measured. Data were analyzed using the SPSS/WIN 20.0 program and Amos 18.0 for descriptive statistics, Pearson correlation coefficients and path analysis. Results: The mean for HRQoL was 80.14. The path analysis showed that depression had the greatest direct effect on HRQoL. It was found that perceived stress had direct and total effects on HRQoL. It also mediated the paths of social support and self-esteem to HRQoL. These factors account for 68% of the total variance, and the fit indices of the model satisfied the criteria of fitness. Conclusion: The results indicate that these factors influencing HRQoL should be considered when developing programs to improve HRQoL for male adults.