This paper aims to examine how Cleopatra, who is the heroine of Shakespeare`s Antony and Cleopatra, overcomes otherness by extricating herself from the dominant racial and sexual discourses of Rome. She is branded a witch and a whore in the play, and is also accused of lustfulness, due to the prevailing stereotype that Egyptians and gypsies were the same race. However, this play gives Cleopatra a variety of subversive strategies, and she is characterized in a non-stereotypical manners. Cleopatra shows her boldness as a female monarch in her relationship with Antony, and she establishes her presence by assuming the figure of the goddess of Isis. Through this strategy, she captivates the generals of Rome, and subverts power relationships. Her cross-dressing creates a crack in Rome`s dominant male ideology. Cleopatra, one of Shakespeare`s most powerful female characters, represents her identity as a woman of strong sexuality and independent voice and boldness, and, accordingly, consolidates her position as a female monarch. Furthermore, by using a variety of subversive strategies, this play debunks the patriarchy of Rome and dominant discourse of colonization.