Purpose: The purpose of this study was to identify the associations of interpersonal relations with irrational beliefs and social supports among nursing students. Methods: Subjects were 149 nursing students attending a university in C city. The data were collected in June, 2018 using questionnaires. The collected data were analyzed by descriptive statistics, t-test, one-way ANOVA, Pearson's correlation coefficient, and multiple regression with the SPSS 23.0 program. Results: There were statistically significant differences by the level of interpersonal relations according to gender (t=3.65, p<.001) and major satisfaction (t=5.04, p=.008). Also, interpersonal relations showed a significant negative correlation with irrational beliefs (r=-.24, p=.003) and a significant positive correlation with social support (r=.44, p<.001). The influencing factor of interpersonal relations were social supports, gender, irrational beliefs and major satisfaction. These factors explained 38.2% of interpersonal relations. Conclusion: Our study finidngs support developing educational and professional training with intepersonal relationships to improve social support as a prospective health care provider.