Purpose: The purpose of this paper is to determine an optimal production time for economic production quantity model with preventive maintenance and random defective rate as the function of a machinery deteriorates. Methods: If a machinery shifts from “in-control” state to “out-of-control” state, a proportion of defective items being produced increases. It is assumed that time to state shift is a random variable and follows an arbitrary distribution. The elapsed time until process shift decreases stochastically as a production cycle repeats and quasi-renewal process is used to implement for production facilities to deteriorate. Results: When the exponential parameter for exponential distribution increases, the optimal production time increases. When Weibull distribution is considered, the optimal production time is closely affected by the shape parameter of Weibull distribution. Conclusion: A mathematical model is suggested to find optimal production time and optimal number of production cycles and numerical examples are implemented to validate the patterns for changes of optimal times under different parameters assumptions. The real application is implemented using the proposed approach.