Purpose: The purpose of this cross-sectional, correlational study was to identify associations of acculturative stress, depression, and quality of life among Indonesian migrant workers living in South Korea. Methods: A total of 91 migrant workers who were recruited in Korea completed paper-and-pencil self-administered questionnaire in September 2018. Acculturative Stress Scale, Patient Health Questionnaire-9, World Health Organization Quality of Life Instrument, Multidimensional Scale of Perceived Social Support (MSPSS), Perceived Organizational Support Scale, and demographic questionnaire were used to measure acculturative stress, depression, quality of life, social support, and organizational support, respectively. We applied descriptive statistics, Pearson’s correlation coefficients, and multiple linear regression analyses with SPSS 22 program. Results: A positive correlation was shown between acculturative stress and depression and a negative correlation was found between acculturative stress and quality of life. Significant factor associated with depression was acculturative stress. Significant factors associated with quality of life were acculturative stress and social support. Conclusion: Our study findings assist nurses to improve the quality of mental health services for Indonesian migrant workers by providing important information such as contact information for health services and counseling and to guide future studies on mental health issues among the population.