The Vortex(1924) of Jose Eustasio Rivera transforms the cruel, violent and hostile Amazon jungle excellently and is estimated as an epic story of tropical nature. The novel shows the perplexity and uneasiness of the narrator in the face of the terrible force of nature and denounces the greedy of the man and the criminal exploitation of nature by the rubber tappers. Also shows that how the instinctive attitudes of the man manifest in a world without laws. Especially, according to the way in which each fictional character exists and his vision of the world, the relations between man and nature are expressed differently. Investigate the type of the man that relates to nature, the elements and the characteristics of nature through the fictional characters would be a shortcut to understand exactly and deeply the theme of the novel. In this article, we will research the relationships established between man and nature. For this, we will understand how greedy, wild and mysterious nature appears, how the fictional characters relate, with what point of view the civilized man looks at nature, how the conflict between man and nature manifests, how is the man's way of existing decided in nature, how the force of nature destroys man.