In 1969, G. Stent has established 1-1 relation between Four emblematic symbols with 4 nitrogenous bases (level 4). In 1973, M. Schonberger was right when he matched four nitrogenous base with four emblematic symbols (in level 4), but at the level of 64 (64 hexagrams and 64 codons), he made some mistakes in the starting point of the calculation, and calculated the results incorrectly. Since the 1980s, many Chinese scholars have set up various options, only Wang LuChi in 2011 calculated correctly at level 64. In 2007, the writer also calculated at level 64 in a correct way.
In this article, through appropriate steps of reasoning, the writer has gradually approached the reasonable options, and finally identified a single option suitable for the similarity between the Genetic code and I Ching. A prerequisite is prisented. One Biochemistry supposition is posed. The writer calculated at the level of 64 (64 Hexagrams and 64 codons) and got a very convincing and nice result. That does not prove that the Book of Changes similar to Genetics but also showed the former reflect the laws of nature.