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논문검색은 역시 페이퍼서치

대한피부과학회지검색

Korean Journal of Dermatology


  • - 주제 : 의약학분야 > 피부과학
  • - 성격 : 학술지
  • - 간기: 월간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : - / SCOPUS
  • - ISSN : 0494-4739
  • - 간행물명 변경 사항 :
논문제목
수록 범위 : 44권 6호 (2006)

원저 : 아토피피부염 학회보고서: 한국인 아토피피부염의 진단기준에 대한 연구

박영립 ( Young Lip Park ) , 김형동 ( Hyung Dong Kim ) , 김규한 ( Kyu Han Kim ) , 김명남 ( Myeung Nam Kim ) , 김진우 ( Jin Wou Kim ) , 노영석 ( Young Suck Ro ) , 박천욱 ( Chun Wook Park ) , 이광훈 ( Kwang Hoon Lee ) , 이애영 ( Ai Young Lee ) , 조상현 ( Sang Hyun Cho ) , 최지호 ( Jee Ho Ch
대한피부과학회|대한피부과학회지  44권 6호, 2006 pp. 659-663 ( 총 5 pages)
4,000
초록보기
Background: Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease with genetic and environmental background. The diagnosis of AD depends on the clinical presentation and history because there are no objective laboratory tests. The criteria established by Hanifin and Rajka have become the standard for the clinical diagnosis of AD (Until now, we used conventional Hanifin and Rajka`s diagnostic guidelines). But diagnostic criteria for Korean have not been studied yet. Objective: The purpose of the present study was to establish the diagnostic criteria of Korean AD. Methods: We made out a draft for diagnostic criteria for Korean on the basis of the Hanifin and Rajka`s guidelines and published Korean journals. And we established the diagnostic criteria for Korean after collecting extensive opinions from dermatologic specialists in many university hospitals. Results: The major criteria of AD is similar to conventional diagnosic criteria, but three additional minor features(periauricular eczema, scalp scale, skin prick test reactivity) were significant for the diagnosis of AD in Korean patients. The other eleven minor features of the conventional minor diagnostic features were also significant. Conclusion: We established Korean diagnostic criteria for AD. Our result suggest that ethnic backgrounds influence the phenotype of AD and that additional three features need to be included in the Korean diagnostic criteria. Continued refinement of these guidelines will facilitate diagnosis in specific ethnic populations and in specific subgroups of patients. (Korean J Dermatol 2006;44(6):659~663)

원저 : 소아,청소년 대상 포진 72예에 대한 임상적 고찰

박수정 ( Soo Jung Park ) , 송현정 ( Hyun Jeung Song ) , 김창욱 ( Chang Wook Kim ) , 이규석 ( Kyu Suk Lee )
대한피부과학회|대한피부과학회지  44권 6호, 2006 pp. 664-668 ( 총 5 pages)
4,000
초록보기
Background: Herpes zoster is a common dermatologic disorder, and the incidence in both adults and children has recently increased. Objective: The aim of this study is to confirm epidemiological features and clinical characteristics of herpes zoster among children and adolescents. Methods: Medical records were reviewed for 72 patients under 18 years old with herpes zoster during an 11-yearperiod from January 1994 to December 2004. These patients were evaluated with regard to gender, age, dermatomal distribution, the interval between varicella and herpes zoster, underlying disease and complication. Results: Children and adolescents (under 18 years old) constituted 5.7% (72 cases of 1,271) of total herpes zoster patients. The ratio of male to female patients was 1:1, and the mean age was 10.0 years. The age distribution was 18% in 0~4 years (13 patients), 27.7% in 5~9 years (20 patients), 33.3% in 10~14 years (24 patients), and 20.8% in 15~18 years (15 patients). Underlying diseases were observed in 52.8% of the patients (38/72 patients). The most common dermatomal distribution was thorasic dermatome (48.6%), followed by trigerminal (23.6%), cervical (15.2%), lumbar (8.3%) and sacral (4.1%) involvement. The complication of herpes zoster was observed in 27.7% of the patients (20/72 patients), and the two most common complications were menigitis (8.3%) and conjunctivitis (8.3%), followed by secondary wound infection (4.1%), generalization of zoster infection (2.7%), Ramsay-Hunt syndrome (2.7%) and postherpetic neuralgia (1.3%). Information on the age onset of varcella was available only in 58.3% of the patients (42/72 patients). The mean age onset of varicella was 2.5 years old, with the peak period between 0~1 years old (17/42 patients). Conclusion: In children and adolescents with herpes zoster, the gender ratio and dermatomal distribution were similar to those previously reported, except for the increased rate of underlying diseases. The incidence of postherpetic neuralgia was also lower than that of adults. Onset of varicella before 1 year of age might be a risk factor for herpes zoster in children and adolescents. (Korean J Dermatol 2006;44(6):664~668)

원저 : 미용사의 직업성 피부질환: 첩포검사 결과에 대한 고찰

박지혜 ( Ji Hye Park ) , 노영석 ( Young Suck Ro )
대한피부과학회|대한피부과학회지  44권 6호, 2006 pp. 669-674 ( 총 6 pages)
4,000
초록보기
Background: Hairdressers are individuals at high risk of occupational skin disease, especially occupational allergic contact dermatitis (OACD), because of continuous exposure to water, detergents, hair dyes and bleaches, permanent wave solutions and metal equipment. Objective: We evaluated the frequency of OACD among hairdressers and the sources of sensitization through patch test and questionnaires. Methods: We analyzed the occupational characteristics (age, gender, duration of work), site of dermatitis, suspicious sensitizers, and use of preventive measures in a group of 96 hairdressers who answered a questionnaire. Among them, 61 hairdressers who were suspected of having occupational allergic contact dermatitis were patch-tested with the Korean standard series and hairdressing series. Results: Among 96 hairdressers, 74 hairdressers (78%) responded with their experiences of work-related skin problems. The results of patch test revealed an occupationally-relevant sensitization in 82% of the 61 hairdressers. Mean frequencies of sensitization ranked as follows: nickel sulfate (37.7%), cobalt chloride (34.4%), paraphenylenediamine base (21.3%), thimerosal (11.5%), potassium dichromate (9.8%), mercury ammonium chloride (8.2%), Balsam Peru (6.6%), glyceryl monothioglycolate (4.9%), and fragrance mix (4.9%). We also classified these allergens as hairdressing agents, and hair dye showed the highest frequency of positive reactions (30%). Conclusion: From this study, we were able to unravel the important sensitizers related to the hairdressing profession. To improve the safety of their job and to the prevent occupational allergic contact dermatitis, hairdressers should be aware of these common sensitizers, and try to improve protective measures and their applications. (Korean J Dermatol 2006;44(6):669~674)

원저 : 한국인 습진성 피부염 환자에서 소양증에 대한 5% Doxepin Cream의 치료 효과

김진영 ( Jin Young Kim ) , 박창근 ( Chang Keun Park ) , 김경일 ( Gyeong Il Kim ) , 김상석 ( Sang Seok Kim ) , 박천욱 ( Chun Wook Park ) , 이철헌 ( Cheol Heon Lee )
대한피부과학회|대한피부과학회지  44권 6호, 2006 pp. 675-680 ( 총 6 pages)
4,000
초록보기
Background: Eczematous dermatitis is associated with severe pruritus, but there are only a few effective treatment modalities. Preliminary studies suggest that topical application of doxepin cream is effective in the treatment of eczematous dermatitis. Objective: This study was undertaken to evaluate the efficacy and safety of topical 5% doxepin cream in reducing pruritus associated with eczematous dermatitis in Korea. Methods: A total of 62 patients with eczematous dermatitis, who daily experienced severe pruritus for at least 1 week, were enrolled in the study. Five percent doxepin cream was applied twice a day on the baseline visit, and four times daily for up to 7 days. We evaluated pruritus scores using visual analog scales, which consisted of a 100-㎜ horizontal line labeled "no itch" and "worst itch imaginable" at opposite ends. Results: Pruritus scores evaluated by patients revealed significantly-better improvement on each visit day. Furthermore, there was a significant decrease in the pruritus scores and erythema evaluated by physicians on each visit day. Furthermore, the most common adverse effects were a stinging sensation and aggravation of erythema at the site of application. Conclusion: Five percent doxepin cream is safe and effective in reducing pruritus in patients with eczematous dermatitis. (Korean J Dermatol 2006;44(6):675~680)

원저 : 대상포진 환자에서 성상신경절 차단술 병용의 효과

안석용 ( Seok Yong Ahn ) , 이영복 ( Young Bok Lee ) , 이광호 ( Kwang Ho Lee ) , 임현교 ( Hyun Kyo Lim ) , 이원수 ( Won Soo Lee ) , 안성구 ( Sung Ku Ahn ) , 최응호 ( Eung Ho Choi )
대한피부과학회|대한피부과학회지  44권 6호, 2006 pp. 681-687 ( 총 7 pages)
4,000
초록보기
Background: Stellate ganglion block has been proposed as one of the effective therapetic modalities for herpes zoster. However, the effect on the reduction of acute herpes zoster pain and postherpetic neuralgia is not well known. Objective: To evaluate the reduction of acute herpes zoster pain and the prevention of postherpetic neuralgia by stellate ganglion block. Methods: Twenty one patients with herpes zoster were included in this study, and were divided into two groups: the group treated with I.V acyclovir, analgesics and stellate ganglion block during 7-days of a hospitalization period, and a control group which were treated with I.V acyclovir and analgesics alone. To evaluate it`s effect on pain, the score of pain presented by patients, where initial pain was defined as 100 and no pain defined as 0, was recorded and compared between the groups. Results: An average day required for the relief of pain was significantly shorter in the treated group than the control group: the average number of days needed to reduce the pain score from 100 to 50, implicating relief of acute pain, was 2.3 days, compared to 3.7 days in the control group (p=0.036). The total duration of pain, implicating postherpetic neuralgia, was also significantly shorter in the treated group (17.4 days) than the control group (42.3 days) (p=0.035). Conclusion: Stellate ganglion block is an effective method which can be used to relieve acute herpes zoster pain involving the trigerminal and cervical nerves, and can prevent postherpetic neuralgia. (Korean J Dermatol 2006;44(6):681~687)

원저 : 여드름 환자의 삶의 질

이상훈 ( Sang Hun Lee ) , 조한석 ( Han Suk Cho ) , 승나르 ( Na Reu Seung ) , 정석준 ( Suck Joon Jung ) , 김철우 ( Chul Woo Kim ) , 조희진 ( Hee Jin Jo ) , 김광호 ( Kwang Ho Kim ) , 김광중 ( Kwang Joong Kim )
대한피부과학회|대한피부과학회지  44권 6호, 2006 pp. 688-695 ( 총 8 pages)
4,000
키워드보기
초록보기
Background: Quality of life (QOL) is a broad concept that encompasses all aspects of an individual`s existence. Acne is a common inflammatory dermatosis which most frequently affects the face, and produces significant psychological and physical scarring. Objective: The aim of this study was to compare QOL in patients with acne and healthy controls by using the WHO QOL Scale, and to assess QOL of patients with acne by using the generic (WHO Quality of life scale), dermatology-specific (Skindex-29) and acne-specific (APSEA) questionnaires. The relationship between clinical characteristics and QOL were explored. Additionally, financial values which patients attach to the treatment for their acne were determined. Methods: 170 acne patients and 41 healthy controls were recruited in this study and completed the WHO QOL-BREF Scale. Total scores and scores of domains of the WHO QOL Scale in the two groups were compared. Correlation analysis and multiple regression analysis were performed to examine the relationship between the quality of life and the clinical characteristics of patients with acne. Results: Total score of WHO QOL scale in patients with acne were decreased compared to those in healthy controls. Clinical characteristics, including the severity of depression and anxiety, disease duration, clinical severity and self-reported severity (SRS), showed significant correlation with QOL. Multiple regression analysis revealed that the severity of depression and anxiety, and SRS were factors directly affecting the QOL in the patients with acne. As for financial aspects, 27.6% of patients would pay 100,000~500,000 won for acne treatment, but 33.5% of patients answered they would not pay when cost of treatment exceeded 100,000 won. Conclusion: QOL in patients with acne was poorer than that of healthy controls. The association between QOL and SRS was stronger than QOL and clinical severity. The severity of depression and anxiety was the most important predictor on QOL. (Korean J Dermatol 2006;44(6):688~695)

원저 : Vibrio vulnificus 패혈증의 임상적 연구

박석돈 ( Seok Don Park ) , 이재영 ( Jae Young Lee ) , 김현대 ( Hyun Dai Kim ) , 윤녕훈 ( Nyung Hoon Yoon )
대한피부과학회|대한피부과학회지  44권 6호, 2006 pp. 696-707 ( 총 12 pages)
4,700
초록보기
Background: Vibrio (V.) vulnificus is a pathogenic marine bacterium that can cause rapid progression of a life-threatening infection. Although V. vulnificus sepsis is well-known to Koreans and was designated as a legal communicable disease in August 2000, many people still become infected each year. Objective: The purpose of this study was to investigate the clinical features of V. vulnificus sepsis, in order to offer basic data for the treatment and prevention of this disease. Methods: We reviewed the available data of 141 patients with V. vulnificus sepsis, which were obtained from 105 patients admitted to hospital and 36 case reports published in the Korean medical journals between 1982 and 2004. Results: Eighty-five percent of patients were 40 to 60 years old. Men were affected 10.5 times more often than women. Patients with underlying chronic diseases (94%) such as alcohol abuse and liver diseases displayed primary sepsis starting with fever, chills, and/or diarrhea, often within 2.3 days of consumption of various kinds of raw seafood. Skin lesions appeared initially as a painful, localized swelling like a bee-sting, followed by edema, blisters, purpura, necrosis and, less commonly, maculopatch, cyanosis, papules, wheals, pustules or erythema multiforme-like lesions. The cutaneous lesions that were present in 91.5% of patients on admission, appeared on the lower extremities in 88.9% of the cases. Of the 141 patients, 88 patients (62.4%) died. The mortality rate increased as initiation of treatment was delayed. Laboratory findings revealed thrombocytopenia and elevated levels of liver enzymes in many tested cases. V. vulnificus was cultivated more easily from the skin lesion (95%) than blood (69%). There were significant differences in systolic blood pressure, leukocyte count and creatinine between survivors and nonsurvivors (p<0.05). V. vulnificus was highly susceptible to several kinds of antibiotics such as ampicillin, ciprofloxacin, and 3rd generation cephalosporins. Mortality rate increased as the delay from the onset of illness to the initiation of treatment was prolonged. Conclusion: Clinicians should promptly initiate appropriate therapy for patients with underlying chronic disease if they exhibit unexplained fever and diarrhea after ingesting raw seafood. (Korean J Dermatol 2006;44(6):696~707)

원저 : 백반증 환자의 각질형성세포와 멜라닌세포에 대한 타크롤리무스의 영향

김효진 ( Hyo Jin Kim ) , 성현철 ( Hyun Chul Sung ) , 박경덕 ( Kyung Duck Park ) , 나건연 ( Gun Yoen Na ) , 이원주 ( Weon Ju Lee ) , 이석종 ( Seok Jong Lee ) , 김도원 ( Do Won Kim )
대한피부과학회|대한피부과학회지  44권 6호, 2006 pp. 708-713 ( 총 6 pages)
4,000
초록보기
Background: Vitiligo is caused by the destruction of melanocytes, however the precise mechanism is still not known. Recently, abnormalities of both humoral and cell-mediated immunity have been documented in patients with this disorder, thus providing a theoretical basis for introducing tacrolimus ointment which works as an immunomodulator in the treatment of vitiligo. Objective: This study was undertaken to examine the effects of tacrolimus on the survival rates of keratinocytes and melanocytes in vitiligo patients, as well as the melanization of melanocytes. Methods: Keratinocytes and melanocytes from the normal skin of 4 vitiligo patients were cultured. They were then treated with various concentrations of tacrolimus (0.01, 0.1, 1, 10, 100μM) for 5 days. Thereafter, MTT (3-(4,5-cimethylthiazol-2-yl)-2,5-di-phenyl tetrazolium bromide) assay and melanin content analysis were performed. Results: Tacrolimus showed no significant effect on the survival rates of keratinocytes. However, a mild proliferative effect on melanocytes was observed at 10μM concentration. On the other hand, marked cytotoxicity was observed at higher than 100μM concentration, and there was no effect under 1μM concentration. The melanin content of individual melanocytes were decreased in proportion to the concentration. Conclusion: These findings indicate that tacrolimus does not have a proliferative effect on keratinocytes and melanocytes in vitiligo patients, and has a tendency to decrease the melanin content in the melanocytes. (Korean J Dermatol 2006;44(6):708~713)

원저 : 손발바닥에 발생한 피부 질환의 조직학적 진단 및 임상적 고찰

강봉선 ( Bong Seon Kang ) , 이정덕 ( Jeong Deuk Lee ) , 조상현 ( Sang Hyun Cho )
대한피부과학회|대한피부과학회지  44권 6호, 2006 pp. 714-720 ( 총 7 pages)
4,000
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초록보기
Background: Palmoplantar dermatoses have frequently been encountered in the dermatologic field. Many previous studies have focused on the specific diseases of palmoplantar dermatoses; however, none of them have included a the comprehensive study of palmoplantar dermatoses. Objective: The purpose of this study was to investigate the epidemiological aspects of palmoplantar dermatoses, with a brief review of the common palmoplantar dermatoses. Methods: We retrospectively reviewed the data of 237 patients who had been biopsied for palmoplantar dermatoses between January 2000 and December 2004 at Our Lady of Mercy Hospital, The Catholic University of Korea. Results: The results were as follows; Female to male ratio was 1:1.01. The mean age at diagnosis was 37.5±20.1 years. The mean duration of the disease was 35.9 months and ranged from 2 days to 50 years. Palmoplantar dermatoses appeared on the palms in 49 (20.6%) patients, the soles in 123 (51.9%) patients, and both the palms and soles in 65 (27.4%) patients. The most common five diseases of palmoplantar dermatoses were palmoplantar pustulosis (23.2%), verruca (11.4%), pompholyx (10.1%), palmoplantar keratoderma (8.9%), and contact dermatitis (8.0%). Of the 237 patients, 65 (27.4%) patients were accompanied with other dermatoses; fungal infection (13.9%), eczema (7.6%), onychodystrophy (3.4%), psoriasis (1.7%), erythema multiforme (1.3%), hyperhidrosis (1.3%), drug eruption (0.8%), or lichen simplex chronicus (0.4%). Of the 237 patients, 51 (21.5%) patients were accompanied with systemic diseases; Cardiovascular diseases (8.4%), endocrine diseases (6.6%), hepatobiliary diseases (4.6%), malignancy (3.4%), pulmonary diseases (2.5%), or gastrointestinal diseases (1.3%). Conclusion: Our study shows that the biopsy of palmoplantar dermatoses is gradually increasing. Further investigation with a wider and larger population is necessary to understand the epidermiology of palmoplantar dermatoses, and, based on the epidermiology of palmoplantar dermatoses, accurate diagnosis and proper treatment of palmoplantar dermatoses could then be achieved. (Korean J Dermatol 2006;44(6):714~720)

원저 : Mohs 미세도식술로 치료한 안면부 기저세포암의 임상 및 병리조직학적 연구

김은정 ( Eun Jung Kim ) , 윤숙정 ( Sook Jung Yun ) , 이지범 ( Jee Bum Lee ) , 김성진 ( Seong Jin Kim ) , 원영호 ( Young Ho Won ) , 이승철 ( Seung Chul Lee )
대한피부과학회|대한피부과학회지  44권 6호, 2006 pp. 721-726 ( 총 6 pages)
4,000
초록보기
Background: The incidence of basal cell carinoma (BCC) has increased in the last decade and is still increasing. Many treatment modalities have been used to treat BCC. Mohs micrographic surgery (MMS) is a specialized type of minimal marginal surgery that offers cure rates superior to other options in the treatment of skin cancers, including BCC. Objective: The purpose of this study is to report our experience of MMS for the treatment of facial BCC and to identify clinical and histological characteristics of BCC treated by MMS. Methods: We analyzed 43 cases of BCC treated by MMS at the Department of Dermatology, Chonnam National University Hospital in Gwangju between March 2003 and September 2005. Results: The mean duration of BCC was 2.5 years, and the mean size was 11.6㎜. The most frequent clinical type of BCC was the pigmented type (44.2%), followed by noduloulcerative (34.9%), and morpheaform type (20.9%). The most common site was the nose (58.1%), followed by the lip (14.0%), eyelid (9.3%), and cheek (7.0%). The most frequent histologic pattern was the nodulocystic type (39.5%), followed by the infiltrative (18.6%), microcystic (11.6%), mixed (11.6%), metatypical (9.3%), and the adenoid type (9.3%). The local flap was the most common method to repair surgical defects (67.4%), followed by primary closure (25.6%), and skin graft (7.0%). None of the cases recurred during 15.2 months (range: 1.5 to 30 months) follow up. Conclusion: Further study will be required for the difference in the rate of curability according to the type of facial BCC treated by MMS. (Korean J Dermatol 2006;44(6):721~726)
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