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논문검색은 역시 페이퍼서치

대한피부과학회지검색

Korean Journal of Dermatology


  • - 주제 : 의약학분야 > 피부과학
  • - 성격 : 학술지
  • - 간기: 월간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : - / SCOPUS
  • - ISSN : 0494-4739
  • - 간행물명 변경 사항 :
논문제목
수록 범위 : 50권 8호 (2012)

원저 : 기저세포암에서 Syndecan-1과 Beta-catenin 발현에 관한 면역조직화학적 연구

김해련 ( Hae Ryun Kim ) , 김민성 ( Min Sung Kim ) , 나찬호 ( Chan Ho Na ) , 신봉석 ( Bong Seok Shin )
대한피부과학회|대한피부과학회지  50권 8호, 2012 pp. 673-678 ( 총 6 pages)
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초록보기
Background: Syndecan-1 and B-catenin are cell adhesion molecules, which are expressed primarily on the surface of adult epithelial cells. The expressions of them have been appeared to be inversely correlated with tumor aggressiveness and invasiveness. Objective: The purpose of this study was to investigate the expression of syndecan-1 and B-catenin in tissue sections of the nodular and high-risk (micronodular and infiltrative type) basal cell carcinomas. Methods: Ten cases of nodular basal cell carcinoma and 10 cases of high-risk basal cell carcinoma (each 5 cases of micronodular and infiltrative type) were investigated. Specimens were assessed for syndecan-1 and B-catenin expression, using a semi-quantitative method in which the intensity of membranous staining was evaluated. Results: In a nodular basal cell carcinoma, syndecan-1 and B-catenin were expressed as similar intensity to normal epidermis. In high-risk basal cell carcinoma, syndecan-1 always showed decreased staining intensity relative to that showed in the normal skin. But, B-catenin showed similar to normal epidermis in the 5 cases, and decreased intensity relative to that of the normal epidermis in the rest. Conclusion: Our results suggest that the decreased expression of syndecan-1 and B-catenin in basal cell carcinoma is associated with the tumor aggressiveness. Especially, of the two adhesion molecules, syndecan-1 is more associated with the high-risk basal cell carcinoma.

원저 : 한국인 만성 특발성 두드러기 환자에서 가려움증의 특징에 대한 임상적 연구

심우행 ( Woo Haing Shim ) , 문제호 ( Je Ho Mun ) , 좌승욱 ( Seung Wook Jwa ) , 송마가렛 ( Margaret Song ) , 김훈수 ( Hoon Soo Kim ) , 고현창 ( Hyun Chang Ko ) , 김문범 ( Moon Bum Kim ) , 김도원 ( Do Won Kim ) , 김병수 ( Byung Soo Kim )
대한피부과학회|대한피부과학회지  50권 8호, 2012 pp. 679-687 ( 총 9 pages)
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초록보기
Background: Although itch is a cardinal symptom of urticaria, its clinical characteristics are not well elucidated in Korean urticaria patients. Objective: To characterize the clinical patterns and sensory, affective and therapeutic dimensions of itch in Korean patients with chronic idiopathic urticaria (CIU). Methods: A face-to-face structured questionnaire based on the McGill pain questionnaire was given to 83 patients with CIU. Results: All of the 83 patients recruited in the study have fully filled-out the questionnaire. In 71.1 percent of the total CIU patients, itch appeared on a daily basis. Patients experienced exacerbation of itch during winter (41.0%) and at night (37.3%). The buttock (50.6%) and front of the thigh (50.6%) were major sites of involvement with itchiness. Patients perceived itch as burning (62.7%), stinging (44.6%) and crawling sensations (42.2%), rather than stabbing (25.3%), tickling (24.1%) and pinching (10.8%). The main associated symptom was heating sensation (60.2%). The majority of the patients answered that itch was annoying (84.3%), worrisome (80.7%) and bothersome (78.3%). Korean CIU patients answered that stress (36.1%) and hot climate (33.7%) aggravated the itch, and medications (55.4%) alleviated it. Among antihistamines, systemic corticosteroids and topical corticosteroids, antihistamines were the most effective treatment for management of itch in patients with CIU. Conclusion: This study highlights the detailed description and characteristics of itch in Korean CIU patients. Moreover, we tried to emphasize the clinical differences of itch in CIU patients in comparison with that in atopic dermatitis patients.

원저 : 한국인 건선환자에서 심·뇌혈관 질환 및 당뇨병 동반에 관한 후향적 연구

이성율 ( Sung Yul Lee ) , 최응호 ( Eung Ho Choi )
대한피부과학회|대한피부과학회지  50권 8호, 2012 pp. 688-692 ( 총 5 pages)
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Background: Psoriasis is now considered as a medical condition that involves not only the skin, but also the other systemic organs. According to the recent studies, psoriasis, especially, the large plaque type, is suggested as a major risk factor of cardiovascular and cerebrovascular disease. However, the prevalence of large plaque type psoriasis is relatively low, among the Asian patients, which leads to a lack of evidence in the population. Objective: This study is performed to evaluate the risk factor of cardiovascular and cerebrovascular disease in psoriasis patients. Methods: After thorough research on the past medical records of the psoriasis patients in our institute, we could classify the four types of psoriasis as guttate psoriasis, small plaque type psoriasis, large plaque type psoriasis, and palmoplantar pustulosis. We enrolled 84 psoriasis patients and 100 dermatologically healthy adults. We divided them into two groups, the psoriasis group and the control group; we compared the prevalence of cardiovascular and cerebrovascular disease between the groups. The psoriasis group was separately recorded by their types of psoriasis. We analyzed the inflammation marker and known risk factor of cardiovascular and cerebrovascular disease, such as total cholesterol, triglyceride, CRP, ESR, fasting glucose, history of diabetes mellitus and hypertension. Results: There was no noticeable difference between the types of psoriasis in all parameters. However, there were statistically significant differences between the psoriasis group and the control group in the parameters of ESR, CRP and prevalence of hypertension and diabetes mellitus. Conclusion: There was no difference in medical co-morbidities and their risk factors between the groups. However, in the psoriasis group, the prevalence of hypertension and diabetes mellitus, which count as the risk factors of cardiovascular and cerebrovascular disease, were higher than the normal control group. Therefore, we suggest that the psoriasis should be considered as a risk factor for cardiovascular and cerebrovascular disease in Korea.

원저 : 안면부에 발생한 피부섬유종 13예에 대한 임상조직학적 고찰

최석주 ( Seok Joo Choi ) , 김정은 ( Jeong Eun Kim ) , 원종현 ( Chong Hyun Won ) , 장성은 ( Sung Eun Chang ) , 이미우 ( Mi Woo Lee ) , 최지호 ( Jee Ho Choi ) , 문기찬 ( Kee Chan Moon )
대한피부과학회|대한피부과학회지  50권 8호, 2012 pp. 693-702 ( 총 10 pages)
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Background: Dermatofibroma (DF) is one of the most common benign soft tissue tumors, and its diagnosis is not difficult if clinicopathologic features are typical. However, DF occurring on the face is very rare; therefore, it is usually missed clinically. Objective: This study was conducted to obtain better understanding of the clinicopathologic features of dermatofibroma of the face. Methods: This is a retrospective study of fibrous histiocytoma of the face at our center over a 23-year period (1989∼2011). Clinicopathologic features of 13 patients were evaluated. Results: Of the 13 patients, ten were female and three were male. The neoplasms presented with various and atypical features, such as nodule, ulceration and papules. Low-power examination revealed that most of the cases were extended beyond the subcutaneous fat layer, showing ill-defined diffuse infiltrative pattern. The most common histologic type was typical fibrocollagenous type, but some cases presented features of cellular or angiomatous type. Mitotic activity was not definite in majority of cases, and usually ranged 0∼1 mitoses per 10 HPF and a few atypical cells were shown in 2 cases, but not accompanied by recurrence. Tumor cells in all cases tested were negative for desmin and CD34, but positive for Factor XIIIa and CD68 in majority of the cases. Conclusion: Because of its rare development on face and diverse clinical presentation, correct diagnosis with differential diagnosis is thought to be important. DF of the face usually presents with infiltration of deeper structures and still shows a benign behavior.

원저 : 영아의 피부질환에 대한 임상적 분석

김화미 ( Hwa Mi Kim ) , 김지연 ( Chi Yeon Kim )
대한피부과학회|대한피부과학회지  50권 8호, 2012 pp. 703-709 ( 총 7 pages)
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Background: The incidence of infantile dermatoses shows a tendency to increase, despite medical development and environmental improvement. Infantile dermatoses must be regarded discretely, due to special characteristics of the neonatal and infantile skin. Objective: The purpose of this study is to evaluate the incidence of dermatologic diseases in the infant patients. Methods: One hundred fifty nine out-patients, younger than 1 year who had visited the department of dermatology from January 2001 to December 2011, were analyzed, retrospectively. Results: The 0∼1 year age group accounted for 0.58% of all new patients (261/44,718). The ratio of male to female was 1 to 0.69. Patients visited the hospital most frequently in the winter (34.5%). The most common disease was atopic dermatitis (30.3%), followed by hemangioma (9.2%), and irritant contact dermatitis (7.7%). The most common disease group was eczema (44.8%), followed by an infectious skin disease (19.2%), and dermal and subcutaneous tumors (10.7%). Conclusion: This study provides useful data on the incidence and characteristics of dermatologic diseases in infant patients.

증례 : 용종모양 무색소성 악성 흑색종 1예

김흥열 ( Heung Yeol Kim ) , 박새보미 ( Sae Bo Mi Park ) , 박은주 ( Eun Ju Park ) , 권인호 ( In Ho Kwon ) , 김광호 ( Kwang Ho Kim ) , 김광중 ( Kwang Joong Kim )
대한피부과학회|대한피부과학회지  50권 8호, 2012 pp. 710-713 ( 총 4 pages)
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초록보기
Amelanotic maliganat melanoma is a comparatively rare disease. It accounts for 1.8∼8.1% of all malignant melanoma. It is sometime difficult to diagnose amelanotic malignant melanoma because there is no pigmentation, clinically. Polypoid melanoma is a variant of nodular melanoma, which in depth seldom reaches the reticular dermis. The main part of the tumor is located above the nearby epidermis, raised in the form resembling cauliflower. We report a rare case of amelanotic malignant melanoma with polypoid feature in a 78-year-old woman who presented a single bright red nodule on the left thigh.

증례 : 자매에서 발생한 선천피부무형성

진상윤 ( Sang Yun Jin ) , 김도훈 ( Do Hun Kim ) , 임원석 ( Won Suk Lim ) , 최윤석 ( Yun Seok Choi ) , 이애영 ( Ai Young Lee ) , 이승호 ( Seung Ho Lee )
대한피부과학회|대한피부과학회지  50권 8호, 2012 pp. 714-717 ( 총 4 pages)
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Aplasia cutis congenita is a rare congenital condition, characterized by localized absence of epidermis, dermis, and in some cases, subcutaneous tissues. About 80% of the patients with aplasia cutis congenita have involvement of the scalp. Aplasia cutis congenita, not involving the scalp, appears to be linear lesions with a symmetrical pattern of distribution on the trunk and limbs. Most reported cases are sporadic, but a few cases have been reported to have familial occurrence. There is no unifying theory for the pathogenesis and etiology. Herein, we report a 1-day-old female infant and her 4-year-old sister with unilateral aplasia cutis congenita on their legs. No similar conditions and other associated congenital anomalies were found in their family. There was no sign of teratogenic causes, such as intrauterine infections, drugs or chemical agents.

증례 : 일광 비노출 부위에 발생한 Papular Elastolytic Giant Cell Granuloma

임원석 ( Won Suk Lim ) , 김도훈 ( Do Hun Kim ) , 진상윤 ( Sang Yun Jin ) , 최윤석 ( Yun Seok Chol ) , 이애영 ( Ai Young Lee ) , 노지현 ( Ji Hyeon Rho ) , 이승호 ( Seung Ho Lee )
대한피부과학회|대한피부과학회지  50권 8호, 2012 pp. 718-721 ( 총 4 pages)
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Papular elastolytic giant cell granuloma is an unusual variant of annular elastolytic giant cell granuloma, characterized by the development of asymptomatic, multiple, small erythematous papules on both sun-exposed and non-sun-exposed area. Histopathologically, it shows a granulomatous infiltration, accompanied by the absence of the elastic tissue and phagocytosis of elastic fibers by multinucleated giant cell. An 83-year-old man was presented with a 1 year history of multiple erythematous papules on his abdomen and lower legs. Histopathologic finding showed a non-palisading granulomatous infiltration with multinucleated giant cells and engulfing elastic fibers. We, herein, report an unusual case of papular elastolytic giant cell granuloma, which occurred on non-sun-exposed skin.

증례 : 골수이형성증후군과 동반된 전신고리육아종

위현승 ( Hyun Seung Wi ) , 윤숙정 ( Sook Jung Yun ) , 김여경 ( Yeo Kyeong Kim ) , 이지범 ( Jee Bum Lee ) , 이승철 ( Seung Chul Lee ) , 원영호 ( Young Ho Won ) , 김성진 ( Seong Jin Kim )
대한피부과학회|대한피부과학회지  50권 8호, 2012 pp. 722-725 ( 총 4 pages)
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Generalized granuloma annulare (GGA) is a rare variant of granuloma annulare, presenting with diffuse papules and annular patches on the trunk and extremities. Though the pathogenesis of GGA has not been totally understood, recent studies have shown the relationship between malignancy and GGA. A 74-year-old man developed a generalized, mildly pruritic erythematous papules, which slowly coalesced into annular patch with elevated rim. Punch biopsy showed palisading and interstitial granuloma with giant cells. A complete blood cell count with differential revealed leukopenia and subsequent findings of the bone marrow biopsy were compatible with myelodysplastic syndrome (MDS). As there was no more progression of MDS, only the skin lesions were treated with hydroxychloroquine, isotretinoin and phototherapy, and improved after 14 months of treatment. We recommend that careful evaluation of the underlying solid tumor, as well as hematologic malignancy, should be done when the dermatologists encounter with the patient presenting generalized granuloma annulare.

증례 : 발바닥에 발생한 모낭 낭종 1예

신지연 ( Ji Yeon Shin ) , 이지현 ( Ji Hyun Lee ) , 김시용 ( Si Yong Kim ) , 김경문 ( Gyong Moon Kim )
대한피부과학회|대한피부과학회지  50권 8호, 2012 pp. 726-729 ( 총 4 pages)
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Trichilemmal cyst is a common, benign, cutaneous tumor, which originates from the external root sheath. It usually occurs on the scalp of middle-aged women. It is rarely found on the face, neck, trunk and extremities. A 33-year-old male presented with a tender, skin-colored, hyperkeratotic, subcutaneous nodule on the right sole for 6 months, without any history of trauma. We clinically diagnosed this skin lesion as a callus. The histopathologic examination showed a well demarcated cystic mass that is lined by a stratified squamous epithelium, without granular layers, and is filled with eosinophilic, amorphous, and homogeneous keratins. The patient was diagnosed with a trichilemmal cyst. Herein, we report a case of trichilemmal cyst of unusual predilection site.
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