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논문검색은 역시 페이퍼서치

대한피부과학회지검색

Korean Journal of Dermatology


  • - 주제 : 의약학분야 > 피부과학
  • - 성격 : 학술지
  • - 간기: 월간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : - / SCOPUS
  • - ISSN : 0494-4739
  • - 간행물명 변경 사항 :
논문제목
수록 범위 : 50권 9호 (2012)

원저 : 피부 발육과정에서 데스모콜린 1의 발현에 관한 면역조직화학적 연구

최지현 ( Ji Hyun Choi ) , 김은정 ( Eun Jung Kim ) , 박향준 ( Hyang Joon Park ) , 조옥자 ( Ok Ja Joh ) , 송계용 ( Kye Yong Song )
대한피부과학회|대한피부과학회지  50권 9호, 2012 pp. 761-767 ( 총 7 pages)
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Background: Desmocollins (Dsc) are calcium-dependent transmembrane glycoproteins of desmosomes that are important in the junction complex of epidermis and maintain structural integrity of the skin from external stressors. Among three Dscs (Dsc 1, 2, 3), Dsc 1 and 3 are distributed on skin. Objective: The purpose of this study was to observe the Dsc 1 distribution pattern on the skin and oral mucosa during fetal development. Methods: Skin was obtained from the sole and scalp of 33 fetuses, ranging from 10 to 37 weeks of gestational age. Immunohistochemical staining was performed on the paraffin-embedded tissue using a Dsc 1 monoclonal antibody. Results: Dsc 1 was expressed in the suprabasal layer but not in the basal layer of the epidermis of the sole at the 10th week of gestation. Thereafter, Dsc 1 expression further increased in the suprabasal layer with initiation of stratification and increased gradually in the granular layers of the sole and scalp epidermis. Dsc 1 was strongly expressed in the superficial layer of the infundibulum and inner root sheath of the hair follicle but was not expressed in the sebaceous cells or other hair components. The eccrine duct epithelium was focally and weakly positive for Dsc 1 expression. Furthermore, Dsc 1 was not expressed in oral mucosa, although the oro-cutaneous portion was strongly expressed in the superficial layer. Conclusion: Dsc 1 was strongly expressed in the suprabasal cells of the epidermis during fetal skin development, and expression increased gradually in the granular layer and inner root sheath of the hair follicle. However, Dsc 1 was not expressed in basal cells or in oral mucosa. Dsc 1 may play a role in the maintenance of epithelial integrity as part of desmosomes.

원저 : 귓볼 켈로이드의 수술 후 보조요법에 따른 재발률에 대한 비교 연구

김희주 ( Hee Joo Kim ) , 정성규 ( Sung Kyu Jung ) , 이경구 ( Kyung Goo Lee ) , 김재환 ( Jae Hwan Kim ) , 김일환 ( Ii Hwan Kim )
대한피부과학회|대한피부과학회지  50권 9호, 2012 pp. 768-772 ( 총 5 pages)
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Background: Earlobe keloids are a cosmetically and symptomatically bothersome clinical problem with frequent recurrence despite various treatments including surgical excision and intralesional injection of corticosteroids. Objective: The aim of this study was to compare the results and recurrence of earlobe keloids after various postexcisional adjuvant therapies and to identify the most effective postoperation adjuvant therapy. Methods: We retrospectively evaluated 36 patients with earlobe keloids (n=71) who underwent core excision and a suprakeloidal flap using photographs. One group did not have adjuvant therapy, one group was treated with adjuvant triamcinolone intralesional injection (TRA/ILI), and another group was treated with postoperative irradiation. Results: Among treated 71 keloids, 18 lesions (25.4%) recurred; 42.9% (12/28) of the operation-only group and 19.4% (6/31) of TRA/ILI group showed recurrence. The adjuvant radiation therapy group had no recurrence. The difference in recurrence rate was statistically significant. Conclusion: Postexcisional adjuvant therapy was more effective than excision monotherapy for keloid treatment, and radiation therapy had more sustained effects than that of TRA/ILI.

원저 : 아토피피부염 환자에서 Cyclosporine 치료용량 및 재발인자에 대한 후향적 연구

노현수 ( Hyun Soo Roh ) , 김정은 ( Jeong Eun Kim ) , 고주연 ( Joo Yeon Ko ) , 노영석 ( Young Suck Ro )
대한피부과학회|대한피부과학회지  50권 9호, 2012 pp. 773-780 ( 총 8 pages)
4,000
초록보기
Background: The clinical efficacy of cyclosporine in the treatment of atopic dermatitis is well documented. However, the optimal dose regimen has not yet been established, and there are few published data about the factors related with relapse after cyclosporine therapy. Objective: The purpose of this study was to provide clues for the proper use of cyclosporine and identify contributing factors for relapse in atopic dermatitis. Methods: We performed a retrospective analysis of 174 patients with atopic dermatitis who had been treated with cyclosporine in our clinic between January 2007 and January 2012. Results: The mean starting dose of cyclosporine was 4.8 mg/kg, and the relief of symptoms was initially achieved with a dose of 5.0 mg/kg. Treatments were continued for 137.2 days with a cumulative dose of 388.0 mg/kg. After discontinuation of cyclosporine, 79/167 (47.3%) patients experienced a relapse, and the duration of remission was 288.6 days. In a multiple regression analysis, serum IgE (p=0.015), starting dose of cyclosporine (p=0.010), and maintenance therapy (p<0.001) were independent and significant factors related to relapse; the relapse and serum IgE, starting dose of cyclosporine showed negative relationship, and maintenance therapy considerably reduced the recurrence rate (odds ratio, 0.04). Conclusion: Our results indicate that higher starting dose of cyclosporine may decrease the relapse rate in atopic dermatitis. In the post-cyclosporine period, subsequent maintenance therapy should also be considered for sustained remission. At the beginning of cyclosporine therapy, initial serum IgE would be a good laboratory index for predicting the risk of relapse.

원저 : 광선 유망상증과 균상 식육종의 병리조직학적 비교 고찰

서기석 ( Kee Suck Suh ) , 박종빈 ( Jong Bin Park ) , 장민수 ( Min Soo Jang ) , 김상태 ( Sang Tae Kim )
대한피부과학회|대한피부과학회지  50권 9호, 2012 pp. 781-787 ( 총 7 pages)
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초록보기
Background: Actinic reticuloid is a severe persistent photodermatitis that usually affects older men. It is characterized by extreme photosensitivity to a broad spectrum of ultraviolet radiation. Actinic reticuloid has many of the clinical and histological features of mycosis fungoides and Sezary syndrome. No Korean studies are available regarding a histopathological and immunohistochemical comparison of actinic reticuloid and mycosis fungoides. Objective: This study was designed to evaluate the histopathological characteristics and conduct a immunophenotypic analysis to distinguish actinic reticuloid from mycosis fungoides. Methods: We reviewed the histomorphological findings of 10 patients diagnosed with actinic reticuloid and those of 15 patients diagnosed with mycosis fungoides from 1996 to 2012 at our clinic. In addition, an immunophenotypic analysis was performed on the skin to assess the proportions of CD4+ and CD8+ T cells in all patients. Results: We found a broad overlap in non-specific inflammatory histological features and more prominent histological features between the two diseases. Irregular acanthosis, vertically-streaked collagen in the papillary dermis, thickened and increased blood vessels, and an eosinophil and plasma cell infiltrate were significantly higher in patients with actinic reticuloid than in those with mycosis fungoides. Stuffed lymphocytes in dermal papillae and a psoriasiform lichenoid pattern were observed significantly more often in patients with mycosis fungoides. Solar elastosis (80%) was seen only in the actinic reticuloid cases. CD8-positive T cells were predominant in the epidermis in eight of 10 patients with actinic reticuloid. In contrast, CD4-positive T cells in the epidermis and dermis predominated in the majority of patients with mycosis fungoides (73.3%) compared with CD8-positive T cells. Conclusion: Histopathological findings and immunophenotypic analyses may be an important adjunct to distinguish actinic reticuloid from mycosis fungoides, but a correlation with clinicopathological findings, phototest, patch test, and photopatchtest is necessary to reliably distinguish actinic reticuloid from mycosis fungoides. Further prospective studies should be conducted on a larger number of cases regarding the differences between actinic reticuloid and mycosis fungoides.

원저 : 농가진의 원인 균주 및 항생제 감수성에 관한 연구

김우중 ( Woo Joong Kim ) , 이경렬 ( Kyung Real Lee ) , 이상은 ( Sang Eun Lee ) , 이희정 ( Hee Jung Lee ) , 윤문수 ( Moon Soo Yoon )
대한피부과학회|대한피부과학회지  50권 9호, 2012 pp. 788-794 ( 총 7 pages)
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Background: Impetigo is a common bacterial infection caused by Staphylococcus aureus, and group Ab-hemolytic Streptococcus or both. Recently, S. aureus has been reported as the most frequently isolated pathogen of impetigo and the incidence of methicillin-resistant S. aureus (MRSA) among patients with impetigo has increased. Objective: To investigate the predominant microorganism and the antibiotic susceptibility of the impetigo causative pathogen. Methods: Bacterial culture and antimicrobial susceptibility testing were performed in patients with impetigo from June 2006 to May 2012. Results: Of 164 patients, bacteria were cultured from 139 patients. Among them, S. aureus was isolated from 114 (82%) patients. The others were Acinetobacter baumannii, Enterobactercloacae, Enterococcus species, Enterococcus faecium, Enterococcus faecalis, Klebsiella oxytoca, and Candida albicans. The resistance rates of S. aureus against antibiotics were as follows: penicillin, 95.6%; erythromycin, 43.9%; fusidicacid, 38.1%; clindamycin, 24.5%; gentamycin, 21%; tetracycline, 12.3%; trimethoprim-sulfamethoxazole, 0.9%; ciprofloxacin, 0%; habekacin, 0%; linezolid, 0%; teicoplanin, 0%; and vancomycin, 0%. Thirty-four (29.8%) S. aureus isolates were MRSA, and the prevalence of MRSA increased during the 6-year period. Conclusion: The most predominant pathogen in impetigo was S. aureus, which was sensitive to ciprofloxacin, habekacin, linezolid, trimethoprim-sulfamethoxazole, teicoplanin, and vancomycin. An increase in the prevalence of MRSA was observed during the 6-year period, and the effective antibiotics for MRSA were trimethoprim-sulfamethoxazole, teicoplanin and vancomycin.

증례 : Cartilage Shaver로 치료한 다발성 모평활근종

서종근 ( Jong Keun Seo ) , 황성환 ( Sung Hwan Hwang ) , 강정난 ( Jeong Nan Kang ) , 홍순권 ( Soon Kwon Hong ) , 이드보라 ( Deborah Lee ) , 성호석 ( Ho Suk Sung )
대한피부과학회|대한피부과학회지  50권 9호, 2012 pp. 795-798 ( 총 4 pages)
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Piloleiomyoma is a benign neoplasm arising from the erector pili muscle in the skin. It occurs as linear or dermatomal arrangements of firm, red to brown intradermal nodules, which are fixed to the skin but not to the deeper tissues. Although various treatments have been attempted, they have shown limited success and several complications remain. A 21-year-old male presented with 3-year history of multiple, erythematous, firm 4 mm to 3 cm sized nodules on the chest, The histopathological examination was compatible with piloleiomyoma, The lesions were removed using the dermal shaving method with a suction-assisted cartilage shaver, Each lesion were markedly flattened. This treatment was quicker and caused less subjective pain to the patient compared with those of classic surgical excision. No signs of adverse events or recurrence have been observed.

증례 : 선상태선에 의한 조갑 익상편

김태욱 ( Tae Wook Kim ) , 문제호 ( Je Ho Mun ) , 좌승욱 ( Seung Wook Jwa ) , 송마가렛 ( Margaret Song ) , 김훈수 ( Hoon Soo Kim ) , 고현창 ( Hyun Chang Ko ) , 김병수 ( Byung Soo Kim ) , 김문범 ( Moon Bum Kim )
대한피부과학회|대한피부과학회지  50권 9호, 2012 pp. 799-802 ( 총 4 pages)
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Pterygium unguis occurs as a result of the scarring process between the proximal nail-fold and matrix and lichen planus is a typical example, although it has also been reported to occur in patients with sarcoidosis or leprosy. Lichen striatus is a childhood linear inflammatory dermatitis of unknown etiology. Many nail changes such as nail-bed hyperkeratosis, nail pitting, longitudinal ridging, onycholysis, and longitudinal fissures have been described in patients with lichen striatus, but pterygium unguis is very rare. It has been suggested that the onset and resolution of onychodystrophy correlates well with the course of skin eruption, but pterygium unguis results in permanent nail changes regardless of skin eruption. A 3-year-old boy presented with a linear papular eruption on the right hand and pterygium on the index finger. He was diagnosed with lichen striatus by histopathological findings, and the papular eruption was resolved with topical tacrolimus ointment, but the pterygium did not improve.

증례 : 피부로 전이된 소세포성 자궁 경부암 1예

이상민 ( Sang Min Lee ) , 한지수 ( Ji Su Han ) , 이지현 ( Ji Hyun Lee ) , 원종현 ( Chong Hyun Won ) , 장성은 ( Sung Eun Chang ) , 이미우 ( Mi Woo Lee ) , 최지호 ( Jee Ho Choi ) , 문기찬 ( Kee Chan Moon )
대한피부과학회|대한피부과학회지  50권 9호, 2012 pp. 803-806 ( 총 4 pages)
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Cervical cancer is the seventh most common malignancy in women, But, not many cases of cutaneous metastasis have been reported, We report a cases of a 45-year-old woman presenting with multiple erythematous nodules on the right flank. She had small cell cervical cancer with multi-organ metastasis, including the pancreas, lymph nodes, and lung. A skin biopsy revealed small cell cancer features throughout the dermis, and immunohistochemical tests were positive for chromogranin and synaptophysin. Based on these clinical and histopathological findings, we concluded that her condition was skin metastasis at the right flank from cervical cancer, which occurs very rarely.

증례 : Etanercept에 의해 유발된 백혈구 파쇄 혈관염

김주하 ( Joo Ha Kim ) , 신원웅 ( Won Ung Shin ) , 백유상 ( Yoo Sang Baek ) , 오칠환 ( Chil Hwan Oh ) , 김재환 ( Jae Hwan Kim )
대한피부과학회|대한피부과학회지  50권 9호, 2012 pp. 807-809 ( 총 3 pages)
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Leukocytoclastic vasculitis is a small vessel inflammatory disease mediated mostly by deposition of immune complexes. Etanercept (Enbrel®) is widely used not only for rheumatic disorders such as ankylosing spondylitis but also for dermatological diseases including psoriasis. Adverse drug reactions including pruritus, angioedema, and skin cancer have been reported. A 35-year-old female presented with palpable purpuric patches that developed on both lower legs 10 months after etanercept administration. A skin biopsy showed characteristic features of leukocytoclastic vasculitis, including perivascular infiltration of neutrophils and lymphocytes with leukocytoclasia and fibrinoid necrosis of the vessel wall. The patient was treated with oral and topical steroids, and the response was excellent and rapid. The patient was administered etanercept to control underlying ankylosing spondylitis. The skin lesions disappeared gradually after 4 weeks, and no other lesions were seen. The number of patients using etanercept has been increasing thus, the possibility of leukocytoclastic vasculitis in patients using etanercept should be considered.

증례 : 크론병에서 Infliximab 치료 중 발생한 농포성 건선 1예

김진용 ( Jin Yong Kim ) , 최미라 ( Mi Ra Choi ) , 조광현 ( Kwang Hyun Cho )
대한피부과학회|대한피부과학회지  50권 9호, 2012 pp. 810-813 ( 총 4 pages)
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Infliximab is a monoclonal antibody that binds and inactivates tumor necrosis factor-a. It has been successfully used to manage diseases associated with a Th1 profile such as psoriasis, Crohn`s disease, and rheumatoid arthritis. A 15-year-old boy presented for erythematous scaly papules and pustules with crust on his entire body, which had appeared initially 2 months ago. He had been treated with infliximab for Crohn`s disease during the last 14 months and had not been diagnosed with psoriasis. A skin biopsy specimen demonstrated papulosquamous dermatitis with subcorneal pustule formation, suggestive of pustular psoriasis. The patient was treated with oral retinoid 20 mg/d for 3 weeks and 10 mg/d for next 3 weeks with concurrent topical steroid, and most lesions disappeared completely with post inflammatory hyperpigmentation. No evidence of recurrence has been observed during 3 months of followup.
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