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Phaleria macrocarpa Suppress Nephropathy by Increasing Renal Antioxidant Enzyme Activity in Alloxan-Induced Diabetic Rats

Phaleria macrocarpa Suppress Nephropathy by Increasing Renal Antioxidant Enzyme Activity in Alloxan-Induced Diabetic Rats

( Asih Triastuti ) , ( Hee Juhn Park ) , ( Jong Won Choi )

- 발행기관 : 한국생약학회

- 발행년도 : 2009

- 간행물 : Natural Product Sciences, 15권 3호

- 페이지 : pp.167-172 ( 총 6 페이지 )


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초록(외국어)
The protective effects of Phaleria macrocarpa (PM) against oxidative stress in diabetic rats were investigated. Diabetes was induced in male Sprague Dawley rats using alloxan (150 mg/kg i.p). After the administration of PM fractions for two weeks the diabetic symptoms, nephropathy and renal antioxidant enzymes were evaluated. The results showed that the oral PM treatments reduced blood glucose levels in diabetic rats. The PM fractions decreased kidney hypertrophy and diminished blood urea nitrogen (BUN) in diabetic rats. Malondialdehyde (MDA), a lipid peroxidation marker, was increased in diabetic animals, but was suppressed by the PM treatments. In addition, the superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities, and glutathione (GSH) level in the alloxan-induced diabetic rats were significantly decreased compared with those in the normal rats, but were restored by PM treatments. The PM fractions also suppressed the level of MDA in the kidney. In conclusion, the anti hyperglycemic and anti-nephropathy of P. macrocarpa may be correlated to the increased renal antioxidant enzyme activity in the kidney.

논문정보
  • - 주제 : 의약학분야 > 약화학
  • - 발행기관 : 한국생약학회
  • - 간행물 : Natural Product Sciences, 15권 3호
  • - 발행년도 : 2009
  • - 페이지 : pp.167-172 ( 총 6 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2012-510-001181195
저널정보
  • - 주제 : 의약학분야 > 약화학
  • - 성격 : 학술지
  • - 간기 : 계간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : - / SCOPUS
  • - ISSN : 1226-3907
  • - 수록범위 : 1995–2022
  • - 수록 논문수 : 1206