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> 한국미생물생명공학회 > Journal of Microbiology and Biotechnology > 22권 1호

Effects of the Synthetic Coprisin Analog Peptide, CopA3 in Pathogenic Microorganisms and Mammalian Cancer Cells

Effects of the Synthetic Coprisin Analog Peptide, CopA3 in Pathogenic Microorganisms and Mammalian Cancer Cells

( In Woo Kim ) , ( Soon Ja Kim ) , ( Yong Nam Kwon ) , ( Eun Young Yun ) , ( Mi Young Ahn ) , ( Dong Chul Kang ) , ( Jae Sam Hwang )

- 발행기관 : 한국미생물생명공학회

- 발행년도 : 2012

- 간행물 : Journal of Microbiology and Biotechnology, 22권 1호

- 페이지 : pp.156-158 ( 총 3 페이지 )


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구매 전에 간행물명, 페이지 수 확인 부탁 드립니다.

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논문제목
초록(외국어)
A synthetic coprisin analog peptide, 9-mer dimer CopA3 (CopA3) was designed based on a defensin-like peptide, Coprisin, isolated from the bacteria-immunized dung beetle Copris tripartitus. Here, CopA3 was investigated for its antimicrobial activity and cancer cell growth inhibition. CopA3 showed antimicrobial activities against various pathogenic bacteria and yeast fungus with MIC values in 2~32 μM ranges, and inhibited the cell viabilities of pancreatic and hepatocellular cancer cells, except MIAPaca2, Hep3B, and HepG2 cells, in a dose-dependent manner. The average IC50 values of CopA3 against pancreatic and hepatocellular cancer cells were 61.7 μM and 67.8 μM, respectively. The results indicate that CopA3 has potential in the treatments of pancreatic and hepatocellular cancers as well as microorganism infection disease.

논문정보
  • - 주제 : 자연과학분야 > 생물
  • - 발행기관 : 한국미생물생명공학회
  • - 간행물 : Journal of Microbiology and Biotechnology, 22권 1호
  • - 발행년도 : 2012
  • - 페이지 : pp.156-158 ( 총 3 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2012-470-002831531
저널정보
  • - 주제 : 자연과학분야 > 생물
  • - 성격 : 학술지
  • - 간기 : 월간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : - / SCOPUS
  • - ISSN : 1017-7825
  • - 수록범위 : 1991–2022
  • - 수록 논문수 : 5943