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> 생화학분자생물학회 > BMB Reports > 28권 3호

Glycation of Copper , Zine - superoxide Dismutase and Its Effect on the Thiol - Metal Catalyzed Oxidation Mediated DNA Damage

Glycation of Copper , Zine - superoxide Dismutase and Its Effect on the Thiol - Metal Catalyzed Oxidation Mediated DNA Damage

Jeen Woo Park , Soo Min Lee

- 발행기관 : 생화학분자생물학회

- 발행년도 : 1995

- 간행물 : BMB Reports, 28권 3호

- 페이지 : pp.249-253 ( 총 5 페이지 )


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논문제목
초록(외국어)
The nonenzymatic glycation of copper, zinc-superoxide dismutase (Cu,Zn-SOD) led to inactivation and fragmentation of the enzyme. The glycated Cu,Zn-SOD was isolated by boronate affinity chromatography. The formation of 8-hydroxy-2`-deoxyguanosine (B-OH-dG) in calf thymus DNA and the generation of strand breaks in pBluescript plasmid DNA by a metal-catalyzed oxidation (MCO) system composed of Fe^(3+), O₂, and glutathione (GSH) as an electron donor was enhanced more effectively by the glycated Cu,Zn-SOD than by the nonglycated enzyme. The capacity of glycated Cu,Zn-SOD to enhance damage to DNA was inhibited by diethylenetriaminepentaacetic acid (DETAPAC), azide, mannitol, and catalase. These results indicated that incubation of glycated Cu,Zn-SOD with GSH-MCO may result in a release of Cu^(2+) from the enzyme. The released Cu^(2+) then likely participated in a Fenton-type reaction to produce hydroxyl radicals, which may cause the enhancement of DNA damage.

논문정보
  • - 주제 : 자연과학분야 > 화학
  • - 발행기관 : 생화학분자생물학회
  • - 간행물 : BMB Reports, 28권 3호
  • - 발행년도 : 1995
  • - 페이지 : pp.249-253 ( 총 5 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2008-470-002204402
저널정보
  • - 주제 : 자연과학분야 > 화학
  • - 성격 : 학술지
  • - 간기 : 월간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : - / SCOPUS
  • - ISSN : 1976-6696
  • - 수록범위 : 1968–2022
  • - 수록 논문수 : 4641