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> 한국응용약물학회 > Biomolecules & Therapeutics(구 응용약물학회지) > 9권 3호

Effects of Rutin on Adhesion Molecules Expression and NO Production Induced by γ - irradiation in Human Endothelial cells

Effects of Rutin on Adhesion Molecules Expression and NO Production Induced by γ - irradiation in Human Endothelial cells

이강노(Kang Ro Lee) , (Eun Wha Son) , (Dong Kwon Rhee) , (Suhk Neung Pyo)

- 발행기관 : 한국응용약물학회

- 발행년도 : 2001

- 간행물 : Biomolecules & Therapeutics(구 응용약물학회지), 9권 3호

- 페이지 : pp.156-161 ( 총 6 페이지 )


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무료
논문제목
초록(외국어)
Inflammation is a frequent radiation-induced following therapeutic irradiation. Treatment of human umbilical endothelial cells (HUVEC) with γ-irradiation (γIR) induces the expression of adhesion proteins such as intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin. Since the upregulation of these proteins on endothelial cell surface has been known to be associated with inflammation, interfering with the expression of adhesion molecules is an important therapeutic target. In the present study, we demonstrate that bioflavonoid rutin inhibits γIR induced expression of ICAM-1, VCAM-1, and E-selectin on HUVEC in a dose- and time dependent manner. Rutin also inhibited yIR induced production of NO. These data suggest that rutin has therapeutic potential for the treatment of various inflammatory disorder associated with an increase of endothelial leukocyte adhesion molecules.

논문정보
  • - 주제 : 의약학분야 > 약화학
  • - 발행기관 : 한국응용약물학회
  • - 간행물 : Biomolecules & Therapeutics(구 응용약물학회지), 9권 3호
  • - 발행년도 : 2001
  • - 페이지 : pp.156-161 ( 총 6 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2009-510-005278916
저널정보
  • - 주제 : 의약학분야 > 약화학
  • - 성격 : 학술지
  • - 간기 : 격월
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : - / SCOPUS
  • - ISSN : 1976-9148
  • - 수록범위 : 1993–2023
  • - 수록 논문수 : 1842