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> 한국생약학회 > Natural Product Sciences > 18권 1호

G0/G1 Cell Cycle Arrest and Activation of Caspases in Honokiol-mediated Growth Inhibition of Human Gastric Cancer Cells

G0/G1 Cell Cycle Arrest and Activation of Caspases in Honokiol-mediated Growth Inhibition of Human Gastric Cancer Cells

( You Jin Kang ) , ( Hwa Jin Chung ) , ( Hye Young Min ) , ( Jayoung Song ) , ( Hyen Joo Park ) , ( Ui Joung Youn ) , ( Kihwan Bae ) , ( Yeong Shik Kim ) , ( Sang Kook Lee )

- 발행기관 : 한국생약학회

- 발행년도 : 2012

- 간행물 : Natural Product Sciences, 18권 1호

- 페이지 : pp.16-21 ( 총 6 페이지 )


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논문제목
초록(외국어)
Honokiol, a naturally occurring neolignan mainly found in Magnolia species, has been shown to have the anti-angiogenic, anti-invasive and cancer chemopreventive activities, but the molecular mechanism of actions has not been fully elucidated yet. In the present study, we investigated the effect of honokiol on the growth inhibitory activity in cultured SNU-638 human gastric cancer cells. We found that honokiol exerted potent anti-proliferative activity against SNU-638 cells. Honokiol also arrested the cell cycle progression at the G0/G1 phase and induced the apoptotic cell death in a concentration-dependent manner. The cell cycle arrest was well correlated with the downregulation of Rb, cyclin D1, cyclin A, cyclin E, and CDK4 expression, and the induction of cyclin-dependent kinase inhibitor p27. The increase of sub-G1 peak by honokiol was closely related to the induction of apoptosis, which was evidenced by the induction of DNA fragmentation, the cleavage of poly (ADP-ribose) polymerase, and the sequential activation of caspase cascade. These findings suggest the cell cycle arrest and induction of apoptosis might be one possible mechanism of actions for the anti-proliferative activity of honokiol in human gastric cancer cell.

논문정보
  • - 주제 : 의약학분야 > 약화학
  • - 발행기관 : 한국생약학회
  • - 간행물 : Natural Product Sciences, 18권 1호
  • - 발행년도 : 2012
  • - 페이지 : pp.16-21 ( 총 6 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2012-510-003212944
저널정보
  • - 주제 : 의약학분야 > 약화학
  • - 성격 : 학술지
  • - 간기 : 계간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : - / SCOPUS
  • - ISSN : 1226-3907
  • - 수록범위 : 1995–2021
  • - 수록 논문수 : 1185