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Silybin Synergizes with Wnt3a in Activation of the Wnt/β-catenin Signaling Pathway through Stabilization of Intracellular β-Catenin Protein

Silybin Synergizes with Wnt3a in Activation of the Wnt/β-catenin Signaling Pathway through Stabilization of Intracellular β-Catenin Protein

( Tae Yeoun Kim ) , ( Sang Taek Oh )

- 발행기관 : 한국미생물생명공학회(구 한국산업미생물학회)

- 발행년도 : 2012

- 간행물 : 한국미생물·생명공학회지, 40권 1호

- 페이지 : pp.50-56 ( 총 7 페이지 )


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논문제목
초록(외국어)
The Wnt/β-catenin signaling pathway regulates diverse developmental processes and adult tissue homeostasis. Inappropriate regulation of this pathway has been associated with human diseases, such as cancers, osteoporosis, and Alzheimer`s disease. Using a cell-based chemical screening with natural compounds, we discovered silybin, a plant flavonoid isolated from the Silybum marianum, which activated the Wnt/β-catenin signaling pathway in a synergy with Wnt3a-conditioned medium (Wnt3a-CM). In the presence of Wnt3a-CM, silybin up-regulated β-catenin response transcription (CRT) in HEK293-FL reporter cells and 3T3-L1 preadipocytes through stabilization of intracellular β-catenin protein. Silybin and Wnt3a-CM synergistically reduced expression of important adipocyte marker genes including peroxisome-proliferator-activated receptorγ (PPARγ) and CAATT enhancer-binding protein α (C/EBPα) in 3T3-L1 preadipocytes, accompanied by the activation of Wnt/β-catenin signaling pathway. Taken together, our findings indicate that silybin is a small-molecule synergist of the Wnt/β-catenin signaling pathway and can be used as a controllable reagent for investigating biological processes that involve the Wnt/β-catenin signaling pathway.

논문정보
  • - 주제 : 자연과학분야 > 생물
  • - 발행기관 : 한국미생물생명공학회(구 한국산업미생물학회)
  • - 간행물 : 한국미생물·생명공학회지, 40권 1호
  • - 발행년도 : 2012
  • - 페이지 : pp.50-56 ( 총 7 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2012-470-003211019
저널정보
  • - 주제 : 자연과학분야 > 생물
  • - 성격 : 학술지
  • - 간기 : 계간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : - / SCOPUS
  • - ISSN : 1598-642x
  • - 수록범위 : 2002–2021
  • - 수록 논문수 : 1185