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> 한국키틴키토산학회 > 한국키틴키토산학회지 > 17권 2호

A Novel Chitosan-Gossypol Based Nanocarrier for Anticancer Curcumin Drug Delivery

A Novel Chitosan-Gossypol Based Nanocarrier for Anticancer Curcumin Drug Delivery

( Ngoan Thi Nguyen ) , ( Lam Dai Tran ) , ( Duong Quang Le ) , ( Dien Gia Pham ) , ( Phuc Xuan Nguyen ) , ( Jun Seo Park ) , ( Jae Kweon Park )

- 발행기관 : 한국키틴키토산학회

- 발행년도 : 2012

- 간행물 : 한국키틴키토산학회지, 17권 2호

- 페이지 : pp.63-67 ( 총 5 페이지 )


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논문제목
초록(외국어)
Gossypol chitosan (GPCS) nanoparticles have been successfully synthesized at the size of 20-40 nm through amidation process to forming base shift of polymer chains of chitosan using gossypol as a crosslinking agent. Their structure was confirmed by Fourier Transformed Infra Red (FT-IR) spectra. Morphology, stability, loading and releasing efficiency of GPCS and Cur/GPCS (Cur stands for curcumin) were thoroughly investigated by Field Emission Scanning Electron Microscopy (FESEM), FT-IR, Ultra Violet-Visible spectrophotometry (UV-Vis) and High Resolve Photoluminescence System (HRPLS). The obtained nanocarrier exhibited an excellent solubility for Cur anticancer drug as well as high stability for in vitro studies. An intensive fluorescence, allowing drug monitor/delivery, was achieved. Drug release profile was also studied. GPCS, therefore, could be considered to be a potential drug carrier for therapeutic treatment.

논문정보
  • - 주제 : 자연과학분야 > 생물
  • - 발행기관 : 한국키틴키토산학회
  • - 간행물 : 한국키틴키토산학회지, 17권 2호
  • - 발행년도 : 2012
  • - 페이지 : pp.63-67 ( 총 5 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2012-470-003092365
저널정보
  • - 주제 : 자연과학분야 > 생물
  • - 성격 : 학술지
  • - 간기 : 계간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : -
  • - ISSN : 1229-4160
  • - 수록범위 : 1996–2021
  • - 수록 논문수 : 1081