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Articles : Structure-Activity Relationship for Antidepressant Effect of Luteolin and Its Related Derivatives Isolated from Taraxacum mongolicum

Articles : Structure-Activity Relationship for Antidepressant Effect of Luteolin and Its Related Derivatives Isolated from Taraxacum mongolicum

( Keum Hee Hwang ) , ( Nam Kyung Lee ) , ( Gun Hee Kim )

- 발행기관 : 한국생약학회

- 발행년도 : 2013

- 간행물 : Natural Product Sciences, 19권 1호

- 페이지 : pp.8-14 ( 총 7 페이지 )


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초록(외국어)
The inhibitory effect and the structure-activity relationships of luteolin and its related derivatives isolated from Taraxacum mongolicum against MAO activities were investigated. The activity-guided isolation of extract from Taraxacum mongolicum led to the isolation of three flavonoids, luteolin, diosmetin, and luteolin-7- glucoside, a polyphenol, chlorogenic acid, a tyrosine and a uridine. The inhibitory activities of luteolin and its related derivatives against MAOs activities are dependent on their molecular structures. The presence of the phenolic hydroxy group at para-position is the active site for MAO-A inhibition as well as of MAO-B. The methoxy group has no potential on MAO-A inhibition. An additional phenolic hydroxy group at the orthoposition alleviates about 4-fold MAO-A inhibitory activity of phenolic hydroxy group at para-position. A carboxylic group seems to be critical for DBH inhibition and has no effects on MAO.

논문정보
  • - 주제 : 의약학분야 > 약화학
  • - 발행기관 : 한국생약학회
  • - 간행물 : Natural Product Sciences, 19권 1호
  • - 발행년도 : 2013
  • - 페이지 : pp.8-14 ( 총 7 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2014-500-001880166
저널정보
  • - 주제 : 의약학분야 > 약화학
  • - 성격 : 학술지
  • - 간기 : 계간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : - / SCOPUS
  • - ISSN : 1226-3907
  • - 수록범위 : 1995–2021
  • - 수록 논문수 : 1174