Purpose: The purpose of this study is to examine the nurse`s role performance and the perception of the importance of role among nurses practicing in a cancer care facility. Methods: A descriptive study design was applied with convenient sampling of 175 nurses working at a cancer care facility in Daegu, Korea. Data was collected using a structured questionnaire from July 1, 2013 to July 5, 2013. Results: Cancer care facility nurse`s role performance score was measured on average 3.23±0.64. Oral medication was the most frequently performed role, followed by encouragement, care related to medication, and pain management. The perception of the importance of nurse`s role was measured on average 3.31±0.35. Care related to medication was regarded as the most important, followed by transfusion, oral medication, and intravenous & intramuscular medication. Nurse`s role performance was different according to nurse`s age (F=3.21, p=.024) and current practice area (F=3.73, p=.012). The perception of the importance of nurse`s role was different only in relation to current practice area (F=6.82, p<.001). Conclusion: Nurses practicing in oncology setting frequently involve encouraging patients and pain management. Training programs designed to facilitate frequently performed and highly regarded nurse`s roles are required for nurses practicing in oncology setting.