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> 대한내과학회 > 대한내과학회 추계학술발표논문집 > 2014권 1호

Poster Session : PS 0878 ; Lower GI Tract : Balsalazide Potentiates The Efficacy of Parthenolide in Human Colorectal Cancer Cells Through inhibition of Nuclear Factor-κb Signaling

Poster Session : PS 0878 ; Lower GI Tract : Balsalazide Potentiates The Efficacy of Parthenolide in Human Colorectal Cancer Cells Through inhibition of Nuclear Factor-κb Signaling

( Seon Min Kim ) , ( Se Lim Kim ) , ( Hyun Young Kim ) , ( Seung Hun Kim ) , ( Inhee Kim ) , ( Seung Ok Lee ) , ( Soo Teik Lee ) , ( Sang Wook Kim )

- 발행기관 : 대한내과학회

- 발행년도 : 2014

- 간행물 : 대한내과학회 추계학술발표논문집, 2014권 1호

- 페이지 : pp.543-543 ( 총 1 페이지 )


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논문제목
초록(외국어)
Background: Balsalazide is an anti-infl ammatory drug used in the treatment of inflammatory bowel disease. Balsalazide can reduce inflammatory response through several mechanisms including inhibition of nuclear factor κB (NF-κB) activity. Parthenolide (PT), a NF-κB inhibitor, has recently been demonstrated as a promising anticancer agent that promotes apoptosis of cancer cells. Methods: In the present study, we investigated the antitumor effect of balsalazide combined with PT by significant inhibition of NF-κB on a human CRC cell line, HCT116. Results: The results demonstrated that combination of balsalazide and PT induced apoptosis which was determined using MTT, cell cycle analysis and annexin-V assay. Combination of balsalazide and PT markedly suppressed nuclear translocation of NF-κB subunit p65 and IκB- phosphorylation. Apoptosis through the mitochondrial pathway under NF-κB signaling was confirmed by detecting regulation of Bcl- 2 family members, cytochrome C release, and activation of caspase 3 and 8. Our data demonstrate that combination of balsalazide and PT inhibits synergistically cell growth and induces apoptotic cell death through blockade of NF-kB signaling pathway. Conclusions: This is the first evidence that combination of balsalazide and PT could be a new regimen for colorectal cancer treatment.

논문정보
  • - 주제 : 의약학분야 > 내과학
  • - 발행기관 : 대한내과학회
  • - 간행물 : 대한내과학회 추계학술발표논문집, 2014권 1호
  • - 발행년도 : 2014
  • - 페이지 : pp.543-543 ( 총 1 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2015-500-000126525
저널정보
  • - 주제 : 의약학분야 > 내과학
  • - 성격 : 학술발표
  • - 간기 : 연간
  • - 국내 등재 : -
  • - 해외 등재 : -
  • - ISSN :
  • - 수록범위 : 1998–2020
  • - 수록 논문수 : 17070