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> 대한내과학회 > 대한내과학회 추계학술발표논문집 > 2014권 1호

Poster Session : PS 0920 ; Lower GI Tract : Lupeol Inhibits LPS Induced P38-Mapk and NF-κB Signaling Pathways, and Attenuates Experimental Colitis in Mice

Poster Session : PS 0920 ; Lower GI Tract : Lupeol Inhibits LPS Induced P38-Mapk and NF-κB Signaling Pathways, and Attenuates Experimental Colitis in Mice

( Chang Hyun Lee ) , ( Jung Won Lee ) , ( Sung Wook Hwang ) , ( Jae Young Chun ) , ( Jong Pil Im ) , ( Joo Sung Kim )

- 발행기관 : 대한내과학회

- 발행년도 : 2014

- 간행물 : 대한내과학회 추계학술발표논문집, 2014권 1호

- 페이지 : pp.554-554 ( 총 1 페이지 )


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논문제목
초록(외국어)
Background: Lupeol, a natural pentacyclic triterpene, is shown to anti-infl ammatory effect but its role in colitis has not been investigated. This study evaluated the effects of lupeol on the p38-MAPK/NF-κB signaling pathways and on experimental colitis. Methods: The human intestinal epithelial cell (IEC)-line COLO 205 and the murine macrophage cell-line RAW264.7 were prepared and subsequently stimulated with lipopolysaccharide (LPS) alone or LPS plus various dose of lupeol. The secretion of IL-8from COLO 205 cell-line was measured by ELISA and the productions of TNF-a, IL-6 and IL-12 from RAW 264.7 cell-line were also qualifi ed by ELISA. The effects of lupeol on IκBa and p38-MAPK phosphorylation, which regulate the production of pro-in- fl ammatory cytokines, were examined by western blotting. In in vivo studies, dextran sulfate sodium (DSS)-induced acute colitis in wild-type mice and chronic colitis in IL- 10-/- mice were treated with or without lupeol. Colitis was quantifi ed by histologic scoring.Results: Lupeol signifi cantly inhibited LPS-induced IκBa and p38-MAPK phosphorylation. The productions of proinfl ammatory cytokines in both IEC and macrophages were also inhibited with lupeol pretreatment. The administration of lupeol signifi cantly reduced the severity of colitis, as assessed based on histology in the both murine colitis models. Conclusions: Lupeol may block the p38-MAPK/IκBa phosphorylation, inhibit the activation of IECs and macrophages, and attenuate experimental murine colitis. These fi ndings suggest that lupeol is a potential therapeutic agent for infl ammatory bowel diseases.

논문정보
  • - 주제 : 의약학분야 > 내과학
  • - 발행기관 : 대한내과학회
  • - 간행물 : 대한내과학회 추계학술발표논문집, 2014권 1호
  • - 발행년도 : 2014
  • - 페이지 : pp.554-554 ( 총 1 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2015-500-000126787
저널정보
  • - 주제 : 의약학분야 > 내과학
  • - 성격 : 학술발표
  • - 간기 : 연간
  • - 국내 등재 : -
  • - 해외 등재 : -
  • - ISSN :
  • - 수록범위 : 1998–2020
  • - 수록 논문수 : 17070