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> 대한피부과학회 > 프로그램북(구 초록집) > 67권 2호

P003 : Phlorizin, an active ingredient of eleutherococcus senticosus, increases proliferative activity of keratinocytes with increased expression of type iv collagen and inhibition of MiR135b

P003 : Phlorizin, an active ingredient of eleutherococcus senticosus, increases proliferative activity of keratinocytes with increased expression of type iv collagen and inhibition of MiR135b

( Jung Tae Park ) , ( Je Byung Chae ) , ( Bo Ri Kim ) , ( Hye Ryung Choi ) , ( Kyung Mi Nam ) , ( Hyun Sun Lee ) , ( Young Soo Kim ) , ( Jongsung Lee ) , ( Akira Date ) , ( Kazumi Toyama ) , ( Kyoung Chan Park )

- 발행기관 : 대한피부과학회

- 발행년도 : 2015

- 간행물 : 프로그램북(구 초록집), 67권 2호

- 페이지 : pp.395-396 ( 총 2 페이지 )


학술발표대회집, 워크숍 자료집 중 1,2 페이지 논문은 ‘요약’만 제공되는 경우가 있으니,

구매 전에 간행물명, 페이지 수 확인 부탁 드립니다.

1,000
논문제목
초록(외국어)
Background: E. senticosus extract (ESE) has been used as an antiaging agent in the skin although it has several systemic beneficial effects. Objectives: The effects of E. senticosus extract (ESE) and its active ingredient phlorizin (PZ) were investigated. Methods: Cultured normal human keratinocytes and skin equivalents are used to test the effects of PZ whether they affect proliferative activity of keratinocytes and how they regulate these effects. Results: The epidermis became slightly thickened on addition of 0.002% ESE. The staining intensity of p63 and proliferating cell nuclear antigen (PCNA) is increased, and integrin メ6 was up-regulated. Analysis of ESE by HPLC and NMR spectroscopy confirmed that PZ is the main ingredient. SE models were treated with PZ and the staining intensity of p63 and PCNA is also increased. Expression of integrin メ6, integrin モ1, and type IV collagen was also increased. Next, levels of miR135b and mRNA levels of integrin メ6, integrin モ1, and type IV collagen were examined in cultured normal human keratinocytes. Levels of mRNA for type IV collagen were increased and levels of miR135b were down-regulated. Conclusion: PZ can affect the proliferative potential of epidermal cells in part by microenvironment changes via miR135b down-regulation and following increased expression of type IV collagen.

논문정보
  • - 주제 : 의약학분야 > 피부과학
  • - 발행기관 : 대한피부과학회
  • - 간행물 : 프로그램북(구 초록집), 67권 2호
  • - 발행년도 : 2015
  • - 페이지 : pp.395-396 ( 총 2 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2016-510-000339275
저널정보
  • - 주제 : 의약학분야 > 피부과학
  • - 성격 : 학술발표
  • - 간기 : 반년간
  • - 국내 등재 : -
  • - 해외 등재 : -
  • - ISSN :
  • - 수록범위 : 1947–2021
  • - 수록 논문수 : 24290